Human non-CG methylation: are human stem cells plant-like?

Epigenetics : Official Journal of the DNA Methylation Society
Olga V DyachenkoSteven S Smith

Abstract

Non-CG methylation is well characterized in plants, where it appears to play a role in gene silencing and genomic imprinting. Although strong evidence for the presence of non-CG methylation in animals has been available for some time, both its origin and function remain elusive. In this review we discuss available evidence on non-CG methylation in animals in light of evidence suggesting that the human stem cell methylome contains significant levels of methylation outside the CG site.

References

Feb 1, 1988·Human Genetics·D N Cooper, H Youssoufian
May 15, 1987·European Journal of Biochemistry·R L AdamsR Eason
Jun 15, 1987·Biochemical and Biophysical Research Communications·D M WoodcockW P Diver
Sep 1, 1985·Cell Differentiation·D N Cooper, S Gerber-Huber
Dec 11, 1982·Nucleic Acids Research·M McClelland, R Ivarie
May 1, 1995·Nature Genetics·S J ClarkM Frommer
Jan 1, 1994·Progress in Nucleic Acid Research and Molecular Biology·S S Smith
Sep 1, 1994·Molecular and Cellular Biology·E S Tasheva, D J Roufa
Sep 1, 1994·Molecular and Cellular Biology·E S Tasheva, D J Roufa
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Mar 21, 1997·The Journal of Biological Chemistry·D M WoodcockW D Warren
May 8, 1997·Biochemical and Biophysical Research Communications·S S Smith, D J Baker
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·X CaoS E Jacobsen
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·B H RamsahoyeR Jaenisch
Oct 18, 2000·The Journal of Biological Chemistry·A FreeA P Bird
May 12, 2001·Science·A M LindrothS E Jacobsen
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·C S MaloneM Teitell
Dec 19, 2003·Current Biology : CB·Xiaofeng CaoSteven E Jacobsen
Aug 7, 2004·Science·Kevin V MorrisDavid J Looney
Apr 21, 2005·The Journal of Biological Chemistry·Sathees C RaghavanMichael R Lieber
Jun 21, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniela CastanottoJohn J Rossi
Oct 26, 2005·Nucleic Acids Research·Taras ShevchukSteven S Smith
Apr 19, 2007·Nucleic Acids Research·Kristofer MunsonSteven S Smith
Oct 30, 2007·Epigenetics : Official Journal of the DNA Methylation Society·Brian WatsonSteven S Smith
Mar 29, 2008·Cell Stem Cell·Julie B Sneddon, Zena Werb
Nov 7, 2008·Methods in Molecular Biology·Tibor A Rauch, Gerd P Pfeifer
Feb 24, 2009·BMC Molecular Biology·Yuliang TanRunsheng Chen
Jul 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marie McGovernE Jane Albert Hubbard
Jul 3, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Borko TanasijevicTheodore P Rasmussen
Sep 8, 2009·Nature Medicine·Piyush B GuptaRobert A Weinberg

❮ Previous
Next ❯

Citations

Sep 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Deborah C Otteson
Feb 19, 2013·Epigenomics·Matthew TruongDavid F Jarrard
May 15, 2012·Biotechnology Journal·Ildiko M L SomorjaiZhong Zhao
Nov 28, 2013·Chemical Communications : Chem Comm·Marie W JohannsenTom Brown
Jun 17, 2015·Annual Review of Genomics and Human Genetics·Yupeng He, Joseph R Ecker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.