Human non-rapid eye movement stage II sleep spindles are blocked upon spontaneous K-complex coincidence and resume as higher frequency spindles afterwards

Journal of Sleep Research
Vasileios Kokkinos, George K Kostopoulos


The purpose of this study was to investigate a potential relation between the K-complex (KC) and sleep spindles of non-rapid eye movement (NREM) stage II of human sleep. Using 58 electroencephalogram electrodes, plus standard electrooculogram and electromyogram derivations for sleep staging, brain activity during undisturbed whole-night sleep was recorded in six young adults (one of them participated twice). NREM stage II spindles (1256 fast and 345 slow) and 1131 singular generalized KCs were selected from all sleep cycles. The negative peak of the KC, the positive peak of the KC (where applicable), and the prominent negative wave peak of slow and fast spindles were marked as events of reference. Fast Fourier transform-based time-frequency analysis was performed over the marked events, which showed that: (a) fast spindles that happen to coincide with KC are interrupted (100% of 403 cases) and in their place a slower rhythmic oscillation often (80%) appears; and (b) spindles that are usually (72% of 1131) following KCs always have a higher frequency (by ∼1 Hz) than both the interrupted spindles and the individual fast spindles that are not in any way associated with a KC. This enhancement of spindle frequency could not be corre...Continue Reading


Jan 1, 1975·International Pharmacopsychiatry·J M Gaillard, R Tissot
Jan 1, 1976·Electroencephalography and Clinical Neurophysiology·L C JohnsonR G Bickford
Oct 1, 1978·Electroencephalography and Clinical Neurophysiology·M W ChurchD M Seales
Jun 1, 1991·Brain : a Journal of Neurology·M HornyakB G Wallin
Dec 1, 1971·Electroencephalography and Clinical Neurophysiology·G Bohlin
Oct 1, 1968·Journal of Projective Techniques & Personality Assessment·D B Pryor
Apr 1, 1994·Journal of the Autonomic Nervous System·S TakeuchiT Watanabe
Oct 1, 1993·Physiology & Behavior·P Halász
Nov 14, 1997·Journal of Sleep Research·J ZeitlhoferB Saletu
Mar 4, 1998·Neuroscience·Florin Amzica, M Steriade
Jan 1, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J ZygierewiczW Androsiuk
Aug 30, 2000·Neuroscience Letters·Luigi De GennaroM Bertini
Sep 21, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·George K Kostopoulos
Mar 1, 2002·Journal of Sleep Research·Sari-Leena HimanenJoel Hasan
Jan 18, 2003·Sleep Medicine Reviews·Florin Amzica, M Steriade
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jens TankRogelio Mosqueda-Garcia
Aug 1, 1956·Electroencephalography and Clinical Neurophysiology·M ROTHJ GREEN
Dec 4, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Giuseppe CurcioLuigi De Gennaro
Jan 28, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kate E CrowleyIan M Colrain
Sep 21, 2005·Sleep·Ian M Colrain
Sep 27, 2006·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Stuart W Hughes, Vincenzo Crunelli
Nov 23, 2006·Nature Neuroscience·David RobbeGyörgy Buzsaki
Mar 21, 2007·Sleep Medicine·Ellen T Kahn-GreeneWilliam D S Killgore
Mar 29, 2007·Journal of Clinical Pharmacology·Richard S Blum
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·M SchabusP Maquet
Feb 28, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Yuko Urakami
Apr 21, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masako TamakiTadao Hori
May 23, 2009·Science·Sydney S CashIstván Ulbert


Jan 18, 2013·PloS One·Andreas KoupparisGeorge K Kostopoulos
Mar 1, 2016·Frontiers in Neuroinformatics·Dimitris SakellariouGeorge K Kostopoulos
Nov 12, 2015·Journal of Biomedical Informatics·Christos P Antonopoulos, Nikolaos S Voros
Mar 9, 2015·Frontiers in Human Neuroscience·Christian O'ReillyJean-Marc Lina
Sep 21, 2017·Frontiers in Human Neuroscience·Roy CoxRobert Stickgold
Jul 4, 2017·Frontiers in Human Neuroscience·Andreas A IoannidesGeorge K Kostopoulos

Related Concepts

Vigilance, Cortical
Surface Electromyography
Sleep Stages
Sleep, REM
Eye Movements

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Related Papers

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Kate E CrowleyIan M Colrain
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Maxime BonjeanMaxim Bazhenov
Cell Calcium
Vincenzo CrunelliStuart W Hughes
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
George K Kostopoulos
© 2021 Meta ULC. All rights reserved