Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

Nature
S GreenP Chambon

Abstract

We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.

References

Jan 1, 1979·Annual Review of Biochemistry·E G Krebs, J A Beavo
Dec 19, 1979·Biochimica Et Biophysica Acta·D P EdwardsW L McGuire
Dec 9, 1985·Nucleic Acids Research·M V GovindanP Chambon
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J P JostM Seldran
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P WalterM Waterfield
Jan 1, 1985·Annual Review of Genetics·K R Yamamoto
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R B MorelandH M Fried
Jan 1, 1984·Journal of Steroid Biochemistry·G L GreeneE V Jensen
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A MigliaccioF Auricchio
Jan 1, 1984·Annual Review of Biochemistry·C O Pabo, R T Sauer
Jan 11, 1980·Nucleic Acids Research·C BenoistP Chambon
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T PatschinskyB M Sefton
Nov 15, 1983·Journal of Molecular Biology·A M FrischaufN Murray
Jul 18, 1983·Biochemical and Biophysical Research Communications·M E Baker
Feb 23, 1984·Nature·W V WelshonsJ Gorski
Jan 1, 1981·Annual Review of Biochemistry·M G Rossmann, P Argos
Feb 25, 1982·Nucleic Acids Research·S GreenR J Beynon
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle

❮ Previous
Next ❯

Citations

Jul 27, 1999·The Journal of Pathology·R A Walker
Mar 1, 1996·International Journal of Cancer. Journal International Du Cancer·E KalkhovenB Van Der Burg
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·S LuoF Labrie
Oct 19, 1999·Synapse·C H LammersM M Mouradian
Aug 1, 1997·Molecular Reproduction and Development·S ErgünM S Davidoff
Oct 10, 1997·Molecular Reproduction and Development·G FlouriotY Valotaire
Sep 27, 2000·International Journal of Cancer. Journal International Du Cancer·S Y AnandappaR Barraclough
Jan 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sonia DupontManuel Mark
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·S SawatsriN Sidell
Sep 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A IkegamiH Orimo
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C K Watts, R J King
May 1, 1994·Journal of Cellular Biochemistry·T Boulikas
Nov 22, 2002·Journal of Neuroscience Research·R E PapkaM Storey-Workley
Dec 1, 1992·Molecular Reproduction and Development·T C WuY J Wan
Jan 7, 2000·Biochemical and Biophysical Research Communications·H TaiS Kato
May 12, 2000·Cell Biology International·A ToescaN Specchia
Nov 1, 1987·Human Genetics·M F Rousseau-MerckR Berger
Mar 1, 1995·Cell and Tissue Research·W D SierraltaH H Thole
Jan 1, 1994·Breast Cancer Research and Treatment·V C Jordan
Jan 1, 1993·Breast Cancer Research and Treatment·K B Horwitz
Jan 1, 1993·Breast Cancer Research and Treatment·R J MiksicekY Wang
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L G RaoT M Murray
Oct 1, 1991·Breast Cancer Research and Treatment·R K SchmutzlerB Schachter
Mar 1, 1995·Journal of Assisted Reproduction and Genetics·O HeikinheimoW E Gibbons
Jan 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R HalabanA Baird
Jun 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E A Berkowitz, M I Evans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.