PMID: 9557772Apr 29, 1998Paper

Human olfactory mucosa in schizophrenia

The Annals of Otology, Rhinology, and Laryngology
G SmutzerS E Arnold

Abstract

Recent evidence indicates that developmental anomalies may underlie some symptoms of schizophrenia, while psychophysical studies have demonstrated olfactory deficits in this disease. The postmortem olfactory mucosa of elderly schizophrenic patients was examined to characterize the molecular phenotype of this tissue. The distribution of developmentally regulated cytoskeletal proteins, a synaptic vesicle protein, a neural marker protein, a receptor for trophic molecules, axonal guidance and cell migration proteins, and neuronal and glial cytoskeletal proteins of various degrees of phosphorylation was examined by immunohistochemistry. Both schizophrenic and control subjects exhibited dystrophic neurites that were immunoreactive for synaptophysin, microtubule-associated proteins (MAP1B), and neurofilament proteins. No major histochemical or morphologic differences in either the expression or distribution of these proteins were observed in the olfactory epithelium of schizophrenic compared to control subjects. These studies indicated that dystrophic neurites frequently occurred in the olfactory mucosa of both schizophrenics and neurologically normal adults. The absence of major immunocytochemical abnormalities suggested that olfacto...Continue Reading

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Citations

Jul 15, 2003·Current Psychiatry Reports·Paul J Moberg, Bruce I Turetsky
Aug 9, 2005·Psychonomic Bulletin & Review·Richard J Stevenson, Trevor I Case
Jun 11, 2005·Schizophrenia Research·Lise RiouxSteven Edward Arnold
Feb 25, 2009·Molecular and Cellular Neurosciences·Marion RichardVéronique Pellier-Monnin
Jun 17, 2008·Neuroscience and Biobehavioral Reviews·Boriana AtanasovaCatherine Belzung
Dec 5, 2000·Journal of Neuroscience Research·G GomezD Restrepo
Jan 30, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Daniel Martins-De-SouzaWagner F Gattaz
Apr 7, 2005·European Archives of Psychiatry and Clinical Neuroscience·Tarik UgurHeinrich Sauer
May 25, 2007·Journal of Proteome Research·Nathalie CueilleBeat M Riederer

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