Human orbital adipose tissue-derived mesenchymal stem cells possess neuroectodermal differentiation and repair ability

Cell and Tissue Research
Darilang MawrieBithiah Grace Jaganathan

Abstract

Mesenchymal stem cells (MSCs) are used extensively in cell therapy for repair and regeneration of several organs and tissues. Cell therapy is a valuable option to treat neurodegenerative diseases and MSCs have been shown to improve neuronal function through direct differentiation or secretion of neurotrophic factors. In the present study, we isolated and characterized stem cells from medial and central orbital adipose tissue and found that they could be grown in a monolayer culture. The orbital adipose tissue-derived cells were identical to bone marrow-derived MSCs in their cell surface marker expression, gene expression and multilineage differentiation abilities. The orbital adipose-derived MSCs (OAMSCs) express several neurotrophic factors, possess neuroectodermal differentiation ability and secreted factors from OAMSCs abrogated neuronal cell damage induced by oxidative stress. Thus, OAMSCs might be a valuable cell source for treatment of neurological diseases and to reverse oxidative damage in the neuronal cells.

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Citations

May 13, 2020·International Journal of Molecular Sciences·Cristina AngeloniTullia Maraldi
Apr 20, 2021·The Journal of Biological Chemistry·Shuwen QianQi-Qun Tang
Jul 13, 2021·World Journal of Stem Cells·Amit SharmaBithiah Grace Jaganathan
Jul 9, 2021·Journal of Cell Communication and Signaling·Sachin Thomas, Bithiah Grace Jaganathan

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Methods Mentioned

BETA
flow cytometry
PCR
flow

Software Mentioned

SPSS
FlowJo

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