Abstract
Prostaglandin E(2) (PGE(2)) and prostaglandin F(2 alpha) (PGF(2 alpha)) have been used for the induction of labor and the termination of pregnancy. Renal excretion is shown to be an important pathway for the elimination of PGE(2) and PGF(2 alpha). The purpose of this study was to elucidate the molecular mechanism of renal PGE(2) and PGF(2 alpha) transport using cells stably expressing human organic anion transporter (hOAT) 1, hOAT2, hOAT3, and hOAT4, and human organic cation transporter (hOCT) 1 and hOCT2. A time- and dose-dependent increase in PGE(2) and PGF(2 alpha) uptake was observed in cells expressing hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, and hOCT2. The K(m) values of PGE(2) uptake by hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, and hOCT2 were 970, 713, 345, 154, 657, and 28.9 nM, respectively, whereas those of PGF(2 alpha) uptake by hOAT1, hOAT3, hOAT4, hOCT1, and hOCT2 were 575, 1092, 692, 477, and 334 nM, respectively. PGE(2) and PGF(2 alpha) significantly inhibited organic anion uptake by hOATs and organic cation uptake by hOCTs. In conclusion, considering the localization of these transporters, the results suggest that PGE(2) and PGF(2 alpha) transport in the basolateral membrane of the proximal tubule is mediated by multiple pat...Continue Reading
References
Nov 15, 1979·The Biochemical Journal·W HsuehP Needleman
Sep 1, 1976·European Journal of Pharmacology·A G Herman, J R Vane
Jan 1, 1986·Kidney International·D Schlondorff, R Ardaillou
Jun 8, 1973·Biochemical and Biophysical Research Communications·C A Leslie, L Levine
Jun 1, 1974·FEBS Letters·A F BradburyD G Smyth
May 12, 1995·Science·N KanaiV L Schuster
Nov 4, 1994·Cell·J E Schaffer, H F Lodish
Dec 8, 1994·Nature·D GründemannH Koepsell
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·E JacqueminP J Meier
Nov 1, 1993·Pflügers Archiv : European journal of physiology·K J UllrichG Fritzsch
Nov 1, 1993·Pflügers Archiv : European journal of physiology·K J UllrichG Fritzsch
Oct 1, 1993·Physiological Reviews·J B Pritchard, D S Miller
Jul 16, 1996·Biochemical and Biophysical Research Communications·M OkudaK Inui
Aug 23, 1996·The Journal of Biological Chemistry·H SaitoK i Inui
Jan 1, 1996·Archives of Toxicology·M HosoyamadaH Endou
Jul 25, 1997·The Journal of Biological Chemistry·T SekineH Endou
Jul 1, 1997·DNA and Cell Biology·V GorboulevH Koepsell
Dec 31, 1997·The Journal of Biological Chemistry·D H SweetJ B Pritchard
Aug 4, 1998·Molecular Pharmacology·A E BuschH Koepsell
May 1, 1999·The Journal of Biological Chemistry·H KusuharaH Endou
Dec 14, 1999·Kidney International·M TakedaH Endou
Feb 8, 2000·The Journal of Biological Chemistry·S H ChaH Endou
Mar 29, 2000·Biochemical and Biophysical Research Communications·H UchinoA Tsuji
Apr 12, 2000·Kidney International·I LeierD Keppler
Aug 23, 2000·Life Sciences·M TakedaH Endou
Feb 24, 2001·Life Sciences·M TakedaH Endou
Apr 18, 2001·Molecular Pharmacology·S H ChaH Endou
Jul 12, 2001·The Journal of Biological Chemistry·G PietigE Schlatter
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·Michio TakedaHitoshi Endou
Jun 14, 2002·Biochimica Et Biophysica Acta·Ellappan BabuHitoshi Endou
Citations
Oct 8, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Stephanie HarlfingerDirk Gründemann
Feb 3, 2005·Pflügers Archiv : European journal of physiology·Giuliano Ciarimboli, Eberhard Schlatter
Oct 29, 2008·Cell Biology and Toxicology·J V Goldstone
Jan 25, 2007·Pharmaceutical Research·Ahsan N Rizwan, Gerhard Burckhardt
May 3, 2007·Pharmaceutical Research·Hermann KoepsellChristopher Volk
Mar 26, 2003·European Journal of Pharmacology·Suparat KhamdangHitoshi Endou
Apr 8, 2003·European Journal of Pharmacology·Atsushi EnomotoHitoshi Endou
May 8, 2010·The Journal of Biological Chemistry·Katsuko ShirayaYoshikatsu Kanai
May 3, 2005·Pharmacogenetics and Genomics·Tomoe FujitaKathleen M Giacomini
Jul 30, 2010·American Journal of Physiology. Renal Physiology·James E ShimaKathleen M Giacomini
Oct 4, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasuna KobayashiToshinori Yamamoto
Nov 11, 2003·Clinical Pharmacokinetics·Susan E TettAndrew J McLachlan
May 10, 2008·Pharmacogenomics·Zoulikha M ZaïrGerd A Kullak-Ublick
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Glen ReidPiet Borst
Jul 30, 2014·Journal of Endodontics·Naoto OhkuraTakashi Okiji
Feb 7, 2016·Experimental Cell Research·Taku KasaiIkumi Tamai
Jul 25, 2006·Expert Opinion on Drug Metabolism & Toxicology·Meng LiJoanne Wang
Nov 25, 2005·Journal of Pharmaceutical Sciences·Tomoe FujitaKathleen M Giacomini
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G Ciarimboli
May 20, 2003·Kidney International·Merlin C ThomasPhillip Kantharidis
Dec 23, 2015·Prostaglandins & Other Lipid Mediators·Tomoka GoseIkumi Tamai
Jul 31, 2012·Pharmacology & Therapeutics·Gerhard Burckhardt
Oct 27, 2015·Frontiers in Pharmacology·Adam G HotchkissRyan M Pelis
Jul 20, 2005·Journal of Neurochemistry·Seng Thuon KhuthJean-François Ghersi-Egea
Nov 30, 2006·The Journal of Pharmacy and Pharmacology·Fumiaki YamashitaYasufumi Sawada
Sep 18, 2012·Journal of Neurochemistry·Masanori TachikawaKen-Ichi Hosoya
Aug 24, 2012·Fundamental & Clinical Pharmacology·Elodie JouanOlivier Fardel
Dec 3, 2009·Biopharmaceutics & Drug Disposition·Adam L VanWertDouglas H Sweet
Jun 29, 2004·Trends in Pharmacological Sciences·Hermann Koepsell
Jul 26, 2005·Biochimica Et Biophysica Acta·Mitsuru SugawaraKatsumi Miyazaki
Nov 19, 2005·European Journal of Pharmacology·Junya NagaiMikihisa Takano
Sep 15, 2005·Biochemical and Biophysical Research Communications·Madoka SakuraiKikuko Watanabe
Aug 29, 2013·BioMed Research International·Elisa LozanoJose J G Marin
Apr 18, 2008·European Journal of Pharmacology·Azza A K El-SheikhFrans G M Russel
Jul 6, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Nobuaki TanakaKen Iseki
Nov 27, 2014·Frontiers in Pharmacology·Darren M MossAndrew Owen
Dec 6, 2014·Nature Reviews. Drug Discovery·Sanjay K Nigam
Jan 16, 2007·Journal of Pharmacological Sciences·Sirinun NilwarangkoonHitoshi Endou
Feb 24, 2004·Journal of Pharmacological Sciences·Suparat KhamdangHitoshi Endou
Oct 3, 2014·PloS One·Nobuaki TanakaNariyasu Mano
Jun 21, 2016·Advanced Drug Delivery Reviews·Fanfan ZhouMichael Murray
Nov 19, 2013·PloS One·Xu HaoNan Chen
Oct 27, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David HahnTsuyoshi Fukuda
Apr 6, 2016·PloS One·Xiao HeGeoffrey Chang
Feb 24, 2017·Journal of Medicinal Chemistry·Eugene C ChenKathleen M Giacomini
Dec 6, 2017·The AAPS Journal·Takeo Nakanishi, Ikumi Tamai
Apr 17, 2018·Journal of Personalized Medicine·Elisa LozanoElisa Herraez
Dec 1, 2017·Scientific Reports·Takeo NakanishiIkumi Tamai
Jul 9, 2004·American Journal of Physiology. Renal Physiology·S SoodvilaiW H Dantzler
Jul 23, 2004·Physiological Reviews·Stephen H Wright, William H Dantzler