Human Organs-on-Chips for Virology.

Trends in Microbiology
Huaqi TangAlireza Mashaghi

Abstract

While conventional in vitro culture systems and animal models have been used to study the pathogenesis of viral infections and to facilitate development of vaccines and therapeutics for viral diseases, models that can accurately recapitulate human responses to infection are still lacking. Human organ-on-a-chip (Organ Chip) microfluidic culture devices that recapitulate tissue-tissue interfaces, fluid flows, mechanical cues, and organ-level physiology have been developed to narrow the gap between in vitro experimental models and human pathophysiology. Here, we describe how recent developments in Organ Chips have enabled re-creation of complex pathophysiological features of human viral infections in vitro.

References

Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier Mestas, Christopher C W Hughes
Sep 25, 2007·Nature Medicine·Juergen PipperLukas Novak
Jan 1, 2009·Future Virology·Jeffrey E Lee, Erica Ollmann Saphire
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber
Nov 19, 2010·Lancet·Heinz Feldmann, Thomas W Geisbert
Dec 15, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Lei GuoBaitang Ning
Jul 9, 2011·Journal of Medical Virology·Javier O CifuenteRicardo M Gómez
Aug 2, 2011·Nature Medicine·Curtis D ChinSamuel K Sia
Nov 9, 2012·Science Translational Medicine·Dongeun HuhDonald E Ingber
Feb 14, 2013·Current Opinion in Virology·David SafronetzHeinz Feldmann
Feb 21, 2013·Nature Communications·Alessandro CumboPatrick Shahgaldian
Aug 6, 2014·Nature Biotechnology·Sangeeta N Bhatia, Donald E Ingber
Sep 30, 2014·Journal of Pineal Research·Dun-Xian TanLucien C Manchester
Nov 21, 2014·PLoS Pathogens·Beatriz Escudero-PérezViktor E Volchkov
Dec 3, 2014·Progress in Neurobiology·Amy M HopkinsDavid L Kaplan
Dec 19, 2014·Lab on a Chip·Andreas O StuckiOlivier T Guenat
Jan 23, 2015·Journal of Medical Virology·George AndersonMoses Rodriguez
Apr 2, 2015·Annals of the American Thoracic Society·Dongeun Dan Huh
Apr 29, 2015·Frontiers in Microbiology·Van Kinh NguyenEsteban A Hernandez-Vargas
Jun 13, 2015·The Journal of Infectious Diseases·Thomas W GeisbertHeinz Feldmann
Aug 22, 2015·Journal of Pineal Research·Thaiz Ferraz BorinDebora Aparecida Pires de Campos Zuccari
Dec 17, 2015·Lab on a Chip·Blake N JohnsonMichael C McAlpine
Feb 18, 2016·The New England Journal of Medicine·Timothy M UyekiUNKNOWN Working Group of the U.S.–European Clinical Network on Clinical Management of Ebola Virus Disease Patients in the U.S. and E
Mar 26, 2016·Biomicrofluidics·Samaneh Mashaghi, Antoine M van Oijen
Apr 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Danny BavliYaakov Nahmias
Nov 9, 2016·Virologica Sinica·Bing HeYi Zeng
Nov 25, 2016·Cell Systems·Nalin Tejavibulya, Samuel K Sia
May 2, 2017·Infection and Drug Resistance·Mazhar HussainMatloob Husain
May 19, 2017·Clinical Pharmacology and Therapeutics·A JainD E Ingber
Sep 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marc RingelhanUlrike Protzer
Oct 27, 2017·Science Translational Medicine·Xiangjun DuMercedes Pascual
Dec 1, 2017·Frontiers in Immunology·Laura Lambert, Fiona J Culley
Feb 15, 2018·Scientific Reports·Magdalena KasendraDonald E Ingber
Mar 3, 2018·Cell Stem Cell·Kacey Ronaldson-Bouchard, Gordana Vunjak-Novakovic

❮ Previous
Next ❯

Citations

Nov 10, 2020·Nucleic Acids Research·Dmitry TworowskiMilana Frenkel-Morgenstern
Nov 27, 2020·Biotechnology and Bioengineering·Huaqi TangAlireza Mashaghi
Nov 22, 2020·The Ocular Surface·Navid ManafiAlireza Mashaghi
Jan 16, 2021·The European Respiratory Journal·Laura GribaldoCatherine Greene
Feb 15, 2021·Trends in Biotechnology·Sasan Jalili-FiroozinezhadJoaquim M S Cabral
Feb 3, 2021·Cell Chemical Biology·Ellen L Berg
Mar 7, 2021·Pathogens·Buket Baddal, Pasquale Marrazzo
Feb 19, 2021·APL Bioengineering·Sushma Kumari, Kaushik Chatterjee
Feb 18, 2021·FEMS Microbiology Reviews·Wouter Van GenechtenLiesbeth Demuyser
Mar 24, 2021·Journal of Molecular Biology·Christopher HopkinsW David Freeman
Mar 23, 2021·Nature Reviews. Materials·Partho Protim AdhikarySarah Hedtrich
Apr 27, 2021·Experimental Biology and Medicine·Passley Hargrove-GrimesDanilo A Tagle
Apr 1, 2021·Clinical and Translational Science·Bérénice CharrezKevin E Healy
Dec 29, 2020·ACS Biomaterials Science & Engineering·Bader M JaraiCatherine A Fromen
May 14, 2021·ACS Nano·Enrique ValeraRashid Bashir
May 15, 2021·Signal Transduction and Targeted Therapy·Hee-Gyeong YiDong-Woo Cho
Jun 4, 2021·Tissue Engineering and Regenerative Medicine·Felipe Allan da Silva da CostaJoão Tadeu Ribeiro-Paes
Jun 15, 2021·Frontiers in Cellular and Infection Microbiology·Benjamin O MurrayJennifer L Rohn
Jul 20, 2021·ACS Biomaterials Science & Engineering·Milica Radisic, Peter Loskill
Jul 9, 2021·Nano Convergence·Shawn KangDan Dongeun Huh
Aug 1, 2021·Drug Discovery Today·Nicole Kleinstreuer, Anthony Holmes
Aug 5, 2021·Lab on a Chip·Jennifer GrantDonald E Ingber
Sep 4, 2021·Cell·Gordana Vunjak-NovakovicMilica Radisic

❮ Previous
Next ❯

Methods Mentioned

BETA
Chip
Chips
single-cell sequencing

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.