Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene

Cytogenetics and Cell Genetics
R WinqvistK Alitalo

Abstract

Using a mouse cDNA probe for ornithine decarboxylase (ODC), we have identified and isolated an ODC cDNA clone from a lambda gt11 recombinant library prepared from human liver cell mRNA. The 2.0-kb insert of this clone hybridizes with several mouse genomic ODC DNA restriction fragments under conditions of low stringency, but reacts with only few human DNA fragments and a polyA+ RNA species of 2.2 kb under both nonstringent and stringent hybridization conditions. This suggests that, unlike the mouse genome, there are only few ODC genes in the human genome. The human ODC DNA fragments segregate with chromosome regions 2pter----p23 and 7cen----qter in mouse X human somatic cell hybrid clones containing normal, translocated, and deleted human chromosomes. Sequences of the short arm of chromosome 2 containing the NMYC oncogene at 2p23----p24 are often involved in DNA amplification in neuroblastomas and small-cell lung cancers. However, in at least three cases--one neuroblastoma cell line, one neuroblastoma tumor, and one lung carcinoma--the ODC sequences are not coamplified with the NMYC oncogene.

Citations

Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·B A Richards-Smith, R W Elliott
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P D'Eustachio
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P D'Eustachio
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Jan 1, 1989·Advances in Enzyme Regulation·J JänneJ Wahlfors
Oct 1, 1989·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·C Rius, P Aller
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R PohlmannG Mersmann
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K W KlingerR Douglas
Sep 15, 1987·Biochemical and Biophysical Research Communications·A P Butler, F F McDonald
Aug 1, 1991·Annals of Medicine·J JänneP Leinonen
Sep 17, 1998·Genes, Chromosomes & Cancer·J L Reiter, G M Brodeur
Sep 1, 1987·Journal of Cellular Physiology·L KaczmarekJ K de Riel
Oct 23, 2013·World Journal of Orthopedics·Takeshi Miyamoto
Apr 20, 1987·Biochimica Et Biophysica Acta·K AlitaloR Winqvist
May 1, 1991·Molecular and Cellular Endocrinology·G ScalabrinoM E Ferioli
Apr 14, 1987·Biochemical and Biophysical Research Communications·L Alhonen-HongistoJ Jänne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.