PMID: 7538609Jan 1, 1994Paper

Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system

The Japanese Journal of Physiology
Kazumitsu UedaT Komano

Abstract

To analyze the mechanism of drug transport, mechanism of inhibitors, and physiological substrates of human P-glycoprotein, we established a transepithelial transport system by introducing MDR1 cDNA into LLC-PK1, a pig kidney epithelial cell line. P-glycoprotein functions as a steroid transporter as well as a drug transporter as physiological functions. P-glycoprotein also transports MDR modulators such as cyclosporin A, FK506, and calcium channel blockers.

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