Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation

American Journal of Physiology. Gastrointestinal and Liver Physiology
Hung-Jen ChienShiue-Cheng Tang

Abstract

The pancreas consists of both the exocrine (acini and ducts) and endocrine (islets) compartments to participate in and regulate the body's digestive and metabolic activities. These activities are subjected to neural modulation, but characterization of the human pancreatic afferent and efferent nerves remains difficult due to the lack of 3-D image data. Here we prepare transparent human donor pancreases for 3-D histology to reveal the pancreatic microstructure, vasculature, and innervation in a global and integrated fashion. The pancreatic neural network consists of the substance P (SP) -positive sensory (afferent) nerves, the vesicular acetylcholine transporter (VAChT) -positive parasympathetic (efferent) nerves, and the tyrosine hydroxylase (TH) -positive sympathetic (efferent) nerves. The SP+ afferent nerves were found residing along the basal domain of the inter-lobular ducts. The VAChT+ and TH+ efferent nerves were identified at the peri-acinar and perivascular spaces, which follow the blood vessels to the islets. In the intra-pancreatic ganglia, the SP+ (scattered minority, ~7%) and VAChT+ neurons co-localize, suggesting a local afferent-efferent interaction. Compared with the mouse pancreas, the human pancreas differs in:...Continue Reading

References

Jan 1, 1992·Pancreas·M BüchlerH G Beger
Jan 15, 1991·Brain Research. Developmental Brain Research·C Kent, P J Clarke
Jan 1, 1989·The American Journal of Physiology·A GéloënL J Bukowiecki
Sep 2, 1998·The American Journal of Physiology·J L Leahy, M S Fineman
Jul 24, 2003·American Journal of Physiology. Endocrinology and Metabolism·Thomas O MundingerGerald J Taborsky
Aug 31, 2004·Journal of Cellular Physiology·Terence M O'ConnorFergus Shanahan
Mar 24, 2005·Pediatric Radiology·Arzu KovanlikayaVicente Gilsanz
Feb 16, 2006·Autonomic Neuroscience : Basic & Clinical·John B Furness
Jul 1, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Antonio GiordanoTimothy J Bartness
Nov 23, 2006·Autonomic Neuroscience : Basic & Clinical·Jeffrey A LoveTina G Smith
Jan 29, 2008·Physiology & Behavior·N A van Herpen, V B Schrauwen-Hinderling
Apr 17, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Savio G BarretoGino T P Saccone
Sep 30, 2010·Diabetes·Rory J McCrimmon, Robert S Sherwin
Oct 12, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T J BartnessC K Song
Feb 10, 2011·Nature Reviews. Gastroenterology & Hepatology·Mark M Smits, Erwin J M van Geenen
Jul 5, 2011·Cell Metabolism·Gerald J Taborsky
Jul 5, 2011·Cell Metabolism·Rayner Rodriguez-DiazAlejandro Caicedo
Sep 8, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-A LiuS-C Tang
Oct 21, 2011·Diabetes·Yasuharu OhtaMichael S German
Mar 7, 2012·Nature Reviews. Gastroenterology & Hepatology·John B Furness
Mar 17, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuan-An LiuShiue-Cheng Tang
Jun 5, 2012·Experimental Physiology·Bashair M Mussa, Anthony J M Verberne
Jun 30, 2012·The Journal of Clinical Endocrinology and Metabolism·Brigid E GreggChristopher J Rhodes
Oct 23, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ya-Yuan FuShiue-Cheng Tang
Mar 9, 2013·Advances in Physiology Education·Denovan P Begg, Stephen C Woods
Jan 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Jyuhn-Huarng JuangShiue-Cheng Tang
Feb 28, 2014·Journal of the American Heart Association·Chih-Yuan WangChih-Jen Chang
Apr 17, 2014·Frontiers in Neuroendocrinology·Timothy J BartnessVitaly Ryu
Oct 16, 2015·Nature Reviews. Gastroenterology & Hepatology·Ihsan Ekin DemirGüralp O Ceyhan
Oct 27, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H-J ChienS-C Tang
Jun 15, 2016·Annual Review of Cell and Developmental Biology·Kazuki TainakaHiroki R Ueda
Jun 25, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pei-Yu LinShiue-Cheng Tang
Jul 20, 2016·Neuropeptides·Qian ShenLei Sha

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Citations

Sep 8, 2020·Diabetologia·Chelsea L FaberGregory J Morton
May 15, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Ömer Cemil SaricaogluIhsan Ekin Demir
Oct 11, 2020·Science Advances·Alexandra AlvarssonSarah A Stanley
Nov 25, 2020·Trends in Neurosciences·Eugene E LinRejji Kuruvilla
Apr 22, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Melinda Wang, Fred Sanford Gorelick
May 14, 2021·Frontiers in Endocrinology·Martha Campbell-Thompson, Shiue-Cheng Tang
May 15, 2021·Frontiers in Endocrinology·Madina Makhmutova, Alejandro Caicedo
Apr 27, 2021·American Journal of Physiology. Endocrinology and Metabolism·Chien-Chia ChenShiue-Cheng Tang
Apr 13, 2021·Endocrine Reviews·John T WalkerAlvin C Powers
Sep 8, 2021·Scandinavian Journal of Gastroenterology·Dag André SangnesEirik Søfteland
Jan 7, 2022·Annual Review of Pharmacology and Toxicology·Zaman MirzadehMichael W Schwartz

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Methods Mentioned

BETA
biopsies
pancreatectomy
confocal microscopy
feature extraction
fluorescence imaging
light microscopy

Software Mentioned

Zen
Avizo
Zeiss Zen
LSM510

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