Human Papilloma Virus Identification in Breast Cancer Patients with Previous Cervical Neoplasia

Frontiers in Oncology
J S LawsonN J Whitaker

Abstract

Women with human papilloma virus (HPV)-associated cervical neoplasia have a higher risk of developing breast cancer than the general female population. The purpose of this study was to (i) identify high-risk HPVs in cervical neoplasia and subsequent HPV positive breast cancers which developed in the same patients and (ii) determine if these HPVs were biologically active. A range of polymerase chain reaction and immunohistochemical techniques were used to conduct a retrospective cohort study of cervical precancers and subsequent breast cancers in the same patients. The same high-risk HPV types were identified in both the cervical and breast specimens in 13 (46%) of 28 patients. HPV type 18 was the most prevalent. HPVs appeared to be biologically active as demonstrated by the expression of HPV E7 proteins and the presence of HPV-associated koilocytes. The average age of these patients diagnosed with breast cancer following prior cervical precancer was 51 years, as compared to 60 years for all women with breast cancer (p for difference = 0.001). These findings indicate that high-risk HPVs can be associated with cervical neoplasia and subsequent young age breast cancer. However, these associations are unusual and are a very small p...Continue Reading

References

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Citations

Jun 3, 2016·British Journal of Cancer·Mette SøgaardDeirdre P Cronin-Fenton
Oct 18, 2016·Frontiers in Oncology·James Sutherland LawsonNoel James Whitaker
Jun 26, 2018·Frontiers in Oncology·Sara BønløkkeSuzan Lenz
Jun 11, 2021·Infectious Agents and Cancer·James S Lawson, Wendy K Glenn

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Methods Mentioned

BETA
light microscopy
PCR
biopsy

Software Mentioned

SPSS
Rotor Gene Q
BLAST

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