Human Papilloma Virus Infection Does Not Predict Response to Interferon Therapy in Ocular Surface Squamous Neoplasia

Ophthalmology
Anat GalorCarol L Karp

Abstract

To identify the frequency of human papilloma virus (HPV) in ocular surface squamous neoplasia (OSSN) and to evaluate differences in clinical features and treatment response of tumors with positive versus negative HPV results. Retrospective case series. Twenty-seven patients with OSSN. Ocular surface squamous neoplasia specimens were analyzed for the presence of HPV. Clinical features and response to interferon were determined retrospectively and linked to the presence (versus absence) of HPV. Clinical characteristics of OSSN by HPV status. Twenty-one of 27 tumors (78%) demonstrated positive HPV results. The HPV genotypes identified included HPV-16 in 10 tumors (48%), HPV-31 in 5 tumors, HPV-33 in 1 tumor, HPV-35 in 2 tumors, HPV-51 in 2 tumors, and a novel HPV in 3 tumors (total of 23 tumors because 1 tumor had 3 identified genotypes). Tumors found in the superior limbus were more likely to show positive HPV results (48% vs. 0%; P=0.06, Fisher exact test). Tumors with positive HPV-16 results were larger (68 vs. 34 mm2; P=0.08, Mann-Whitney U test) and were more likely to have papillomatous morphologic features (50% vs. 12%; P=0.07, Fisher exact test) compared with tumors showing negative results for HPV-16. Human papilloma viru...Continue Reading

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Citations

Jun 1, 2018·Archives of Pathology & Laboratory Medicine·Mehenaz Hanbazazh, Kymberly A Gyure
Mar 16, 2019·Expert Review of Clinical Immunology·Anne-Mieke J W HaasnootJoke H de Boer
Jun 8, 2017·International Ophthalmology·Alfonso IovienoLuigi Fontana
Jul 22, 2018·Ophthalmology and Therapy·Maria Vittoria CicinelliGiulio Modorati
Nov 30, 2016·International Ophthalmology Clinics·Joy N CarrollSahar Kohanim
Feb 12, 2017·Expert Review of Ophthalmology·Ibrahim O Sayed-AhmedCarol L Karp
Feb 11, 2021·Eye·Roland HӧllhumerPamela Michelow

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