Human papilloma virus type 16 infection and the early onset of cervical cancer

Biochemical and Biophysical Research Communications
Akihiro KarubeToshinobu Tanaka

Abstract

Human papilloma viruses (HPV), particularly type 16, have been associated with cervical cancer. It has been noted that the average onset of cervical cancer is occurring in younger women coupled with a higher prevalence of cervical HPV infection. However, the correlation between HPV 16 infection and the early onset of cervical cancer is still unclear. We hypothesize that HPV infection is an indicator of early onset of cervical cancer. To test this hypothesis, cervical smears from 197 women were evaluated by the polymerase chain reaction for HPV 16. These data revealed that the HPV 16-positive women were significantly younger than the HPV 16-negative women. Moreover, the average age of HPV 16-positive women with CIN 3 or invasive cancer was significantly younger compared with the other groups. These data clearly suggest that HPV 16 infection is a significant risk factor for the progression for cervical cancer in a young population of women.

References

Jun 19, 1992·International Journal of Cancer. Journal International Du Cancer·J ter MeulenX Yu
Jun 19, 1992·International Journal of Cancer. Journal International Du Cancer·C Mugica-Van HerckenrodeD V Coleman
Mar 7, 2002·Journal of the National Cancer Institute·Masahiro SasakiRajvir Dahiya
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Elaine M SmithLubomir P Turek
Mar 3, 2004·Obstetrics and Gynecology·Vicki B BenardNancy C Lee
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masahiro SasakiRajvir Dahiya

❮ Previous
Next ❯

Citations

Oct 1, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jennifer S SmithJeanne M Pimenta
Sep 27, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yuping WuYing He
Jan 25, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Natalie GrundmeierAndreas Kerstan
Dec 17, 2008·Cadernos de saúde pública·Michele Lopes PedrosaRosalina Jorge Koifman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.