PMID: 9187902Jan 1, 1997Paper

Human papillomavirus 16 and 18 infection is absent in urinary bladder carcinomas

European Urology
Q L LuP Abel

Abstract

The role of human papillomavirus (HPV) in the pathogenesis of bladder neoplasia remains controversial. Studies to date have mainly utilized polymerase chain reaction and DNA blot techniques to detect HPV DNA. The detection rates have varied from 0 to 81%. One of the major limitations of these techniques is that they lack topographic information. We have used a highly sensitive in situ hybridization (ISH) technique which detects single copies of viral genome and provides topographic information for investigation of HPV infection in bladder carcinomas. Thirty-one samples of formalin-fixed paraffin-embedded bladder carcinomas (4 adenocarcinomas, 5 squamous cell and 22 transitional cell carcinomas) were examined using non-isotopic ISH with biotin-labelled DNA probes of HPV 16 and 18 subtypes. HPV-positive skin and anal carcinoma samples were used as controls. No positive signals for HPV 16 or 18 were detected in any of the bladder carcinoma samples. Given the sensitivity of the technique, the result indicates that HPV 16 and 18 are not implicated in the development of bladder neoplasia compared to certain other epithelial malignancies. The possibility that other subtypes of HPV contribute to bladder epithelial carcinogenesis remain...Continue Reading

Citations

Aug 1, 2013·Archives of Pathology & Laboratory Medicine·Jennifer Rose Chapman-FredricksMercè Jordà
Oct 22, 2013·Urologic Oncology·Yanis TolstovStefan Duensing
Apr 30, 2010·Medical Oncology·Dilek YavuzerDilek Sakirahmet
Jul 20, 2010·Pathology Oncology Research : POR·Ioannis N MammasDemetrios A Spandidos
Oct 2, 2015·The American Journal of Surgical Pathology·Lauren E SchwartzJonathan I Epstein
Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kit Riegels Jørgensen, Jørgen Bjerggaard Jensen
Apr 3, 2020·Current Opinion in Urology·Benjamin PradereReza Sari Motlagh
Jul 7, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elen B BlochinHikmat Al-Ahmadie

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