Feb 23, 2007

Human papillomavirus 16 and head and neck squamous cell carcinoma

International Journal of Cancer. Journal International Du Cancer
C Sloane FurnissKarl T Kelsey

Abstract

Evidence suggests that human papillomavirus (HPV)16 seropositivity reflects past HPV16 exposure and is associated with risk for head and neck squamous cell carcinoma (HNSCC). Our objectives were to test the hypothesis that HPV16 seropositivity is associated with risk for HNSCC, to correlate HPV16 seropositivity with HPV16 tumor DNA, and to correlate HPV16 seropositivity and HPV16 DNA with sexual history and patient survival. In a case-control study of approximately 1,000 individuals, we assessed serology to the HPV16 L1 protein and in cases only, assayed tumors for HPV16 DNA. HPV16 seropositivity was associated with 1.5- and 6-fold risks for tumors of the oral cavity and pharynx, respectively. There was a dose response trend for HPV16 titer and increasing risk of HNSCC (p < 0.0001) and HPV16 tumor DNA (p < 0.0001). In cases, HPV16 DNA and seropositivity were significantly associated with sexual activity; odds ratios (ORs) of 12.8 and 3.7 were observed for more than 10 oral sexual partners and ORs of 4.5 and 3.2 were associated with a high number of lifetime sexual partners, respectively. Finally, HPV16 seropositivity and HPV16 tumor DNA were associated with hazard ratios of 0.4 and 0.5, respectively, indicating better survival ...Continue Reading

Mentioned in this Paper

Entire Oral Cavity
Human Papillomavirus
Malignant Neoplasm of Pharynx
Neoplasms
Gastroschisis
Squamous Cell Carcinoma of the Head and Neck
Study of Serum
Human Papillomavirus Infection in Conditions Classified Elsewhere and of Unspecified Site
Entire Pharynx
Squamous Cell Carcinoma

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