Human papillomavirus and skin cancer

The Journal of Investigative Dermatology. Symposium Proceedings
A Bennett JensonS Ghim

Abstract

Human papillomavirus (HPV) appears to be the most ubiquitous of the human viruses. Over 100 HPV types have been identified. A minority of HPV cause cutaneous warts and mucosal condylomata. The HPV that cause mucosal condylomata put the patient at various degrees of risk for developing cancers, particularly cervical cancer. The majority of HPV infect the skin of normal and immunocompromised individuals. In normal people, most of these HPV appear to establish a latent infection of the skin, most likely as normal flora residing in hair follicles; however, in patients with various systemic and localized depressions of cell-mediated immunity, some HPV infections appear to be involved in the development of nonmelanotic skin cancer and its precursor lesions in skin, usually in sunlight-exposed areas. Circumstantial evidence suggests that these HPV may have a role in promoting proliferative lesions of the skin, although their sites of active infection and mode of transmission to susceptible individuals remain unknown.

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Citations

Oct 27, 2007·Actas dermo-sifiliográficas·R Corbalán-VélezF J Carapeto
Jan 20, 2009·Journal of Medical Virology·Wei-Sheng WangChin Li
Aug 14, 2012·Journal of Cutaneous Pathology·Jade Wititsuwannakul, Christine J Ko
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Oct 12, 2012·The American Journal of Dermatopathology·Jade WititsuwannakulChristine J Ko

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