Human papillomavirus and vaccination in cervical cancer

Taiwanese Journal of Obstetrics & Gynecology
Kung-Liahng Wang

Abstract

Cervical cancer is not only the most frequently reported cancer among women, but also the most common female genital tract neoplasm in Taiwan. Early detection is effective, because the development, maintenance and progression of precursor lesions (cervical intraepithelial neoplasia [CIN]) evolve slowly into invasive cancer, typically over a period of more than 10 years. It is now recognized that human papillomavirus (HPV) infection is a necessary cause for over 99% of cervical cancer cases. Advances in the understanding of the causative role of HPV in the etiology of high-grade cervical lesions (CIN 2/3) and cervical cancer have led to the development, evaluation and recommendation of HPV-based technologies for cervical cancer prevention and control. The prevention of HPV infection before the onset of CIN is now possible with recently available prophylactic HPV vaccines, e.g. the quadrivalent Gardasil (Merck & Co., NJ, USA) and bivalent Cervarix (GlaxoSmithKline, London, UK). This review article provides an up-to-date summary of recent studies and available information concerning HPV and vaccination in cervical cancer.

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Citations

Sep 12, 2013·Archives of Virology·Heena MalikHaseeb Ahsan
Aug 2, 2013·The Journal of Family Planning and Reproductive Health Care·Harriet L BowyerJo Waller
Mar 13, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Hedia BelhadjNathalie Broutet
Oct 4, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marcus V A BatistaValdir Q Balbino
Oct 12, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Monika KauravRavi Shankar Pandey

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