Human papillomavirus and vaccination in cervical cancer

Taiwanese Journal of Obstetrics & Gynecology
Kung-Liahng Wang


Cervical cancer is not only the most frequently reported cancer among women, but also the most common female genital tract neoplasm in Taiwan. Early detection is effective, because the development, maintenance and progression of precursor lesions (cervical intraepithelial neoplasia [CIN]) evolve slowly into invasive cancer, typically over a period of more than 10 years. It is now recognized that human papillomavirus (HPV) infection is a necessary cause for over 99% of cervical cancer cases. Advances in the understanding of the causative role of HPV in the etiology of high-grade cervical lesions (CIN 2/3) and cervical cancer have led to the development, evaluation and recommendation of HPV-based technologies for cervical cancer prevention and control. The prevention of HPV infection before the onset of CIN is now possible with recently available prophylactic HPV vaccines, e.g. the quadrivalent Gardasil (Merck & Co., NJ, USA) and bivalent Cervarix (GlaxoSmithKline, London, UK). This review article provides an up-to-date summary of recent studies and available information concerning HPV and vaccination in cervical cancer.


Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R KirnbauerJ T Schiller
Jul 17, 1991·Journal of the National Cancer Institute·C LeyM M Manos
Jan 23, 1991·JAMA : the Journal of the American Medical Association·H M BauerM M Manos
Sep 20, 1995·Journal of the National Cancer Institute·G Y HoS Romney
Jul 1, 1994·Pediatric Annals·L D Frasier
Sep 1, 1996·Gynecologic Oncology·P D Wang, R S Lin
Feb 12, 1998·The New England Journal of Medicine·G Y HoR D Burk
Mar 27, 1999·Lancet·J Thomas Cox
May 11, 1999·JAMA : the Journal of the American Medical Association·M M ManosR A Hiatt
Aug 19, 1999·The Journal of Pathology·J M WalboomersNubia Muñoz
Dec 10, 1999·International Journal of Cancer. Journal International Du Cancer·P KoskelaJ Paavonen
Mar 14, 2000·Seminars in Cancer Biology·J Dillner
Mar 31, 2000·Molecular Medicine Today·P K Magnusson, U B Gyllensten
May 18, 2000·Journal of the National Cancer Institute·L KuhnT C Wright
Jun 30, 2001·JAMA : the Journal of the American Medical Association·Anna-Barbara MoscickiJoel M Palefsky
Jan 5, 2002·JAMA : the Journal of the American Medical Association·N F SchlechtEduardo L Franco
Feb 16, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Stuart CollinsCiaran B J Woodman
Mar 29, 2002·Journal of Clinical Pathology·F Xavier BoschK V Shah
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Thomas C WrightASCCP-Sponsored Consensus Conference
Jul 23, 2002·Journal of Medical Screening·P Sasieni, J Cuzick
Sep 3, 2002·Statistics in Medicine·Petra MacaskillEduardo L Franco
Sep 19, 2002·Journal of the National Cancer Institute·Philip E CastleMark Schiffman
Nov 26, 2002·Virus Research·Karl Münger, Peter M Howley
Jan 21, 2003·Emerging Infectious Diseases·Gillian D Sanders, Al V Taira
Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozInternational Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Apr 23, 2003·Cancer Letters·Antonio FregaAldo Vecchione
Jun 10, 2003·Clinical Journal of Oncology Nursing·Wendy M Likes, Joanne Itano
Jun 26, 2003·American Journal of Obstetrics and Gynecology·ASCUS-LSIL Traige Study (ALTS) Group
Aug 15, 2003·International Journal of Cancer. Journal International Du Cancer·Sue J GoldieEduardo L Franco
Dec 20, 2003·Cancer Causes & Control : CCC·Martyn PlummerIARC Multi-centre Cervical Cancer Study Group
Dec 24, 2003·The Cancer Journal·Diane D Davey
Jun 9, 2004·Virology·Ethel-Michele de VilliersHarald zur Hausen
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anco MolijnLeen-Jan van Doorn
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Nov 29, 2005·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Anna-Barbara Moscicki
Dec 27, 2005·The Lancet Infectious Diseases·Jeffrey M Partridge, Laura A Koutsky
Jan 13, 2006·Vaccine·Helen Trottier, Eduardo L Franco


Sep 12, 2013·Archives of Virology·Heena MalikHaseeb Ahsan
Aug 2, 2013·The Journal of Family Planning and Reproductive Health Care·Harriet L BowyerJo Waller
Mar 13, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Hedia BelhadjNathalie Broutet
Oct 4, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marcus V A BatistaValdir Q Balbino
Oct 12, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Monika KauravRavi Shankar Pandey

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.