Human Papillomavirus Assays and Cytology in Primary Cervical Screening of Women Aged 30 Years and Above

PloS One
Matejka ReboljElsebeth Lynge

Abstract

In women aged ≥ 30 years, Human Papillomavirus testing will replace cytology for primary cervical screening. We compared Hybrid Capture 2 (HC2), cobas, CLART, and APTIMA HPV assays with cytology on 2869 SurePath samples from women undergoing routine screening at 30-65 years in Copenhagen, Denmark. Women with cytological abnormalities were managed according to routine recommendations, with 92% completeness. Those with cytology-normal/HPV-positive samples (on any of the four assays) were invited for repeated cytology and HPV testing in 1.5 year, and 58% had additional testing. HPV testing detected more ≥ CIN3 than cytology (HC2: 35, cobas, CLART: 37, APTIMA: 34, cytology: 31), although statistically the differences were not significant. Cobas and CLART detected significantly more ≥ CIN2 than cytology (cobas, CLART: 49, cytology: 39). The proportion of women with false-positive test results (positive test results without ≥ CIN3) varied between 3.3% with cytology and 14.9% with cobas. All HPV assays led to significantly more false-positive tests, whereas compared to HC2 cobas and CLART were associated with a significantly higher and APTIMA with a significantly lower proportion. Detection of CIN1 was particularly increased for the t...Continue Reading

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Citations

Nov 30, 2016·BMC Cancer·Cornelis Johannes Jacobus HuijsmansAdrianus Johannes Christiaan van den Brule
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Methods Mentioned

BETA
Assay
biopsy
biopsies
Profiler
PCR

Software Mentioned

Patobank
APTIMA
Cobas

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