Human Papillomavirus-Associated Oropharyngeal Cancer: Defining Risk Groups and Clinical Trials.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Aarti Bhatia, Barbara Burtness

Abstract

Human papillomavirus-associated oropharynx cancer (HPVA-OPC) is rapidly increasing in incidence and has unique epidemiologic, molecular, and biologic characteristics. Despite being recognized as having superior prognosis, current evidence does not support less intense therapy compared with HPV-negative OPC. Current combined modality therapies confer a significant risk of morbidity, and patients with HPVA-OPC have a younger median age. These patients, therefore, live longer with the adverse effects of treatment, and this spurs the development of treatment deintensification trials that attempt to decrease treatment-related morbidity without compromising efficacy. Many radiation and chemotherapy de-escalation trials are underway. Minimally invasive surgical techniques are also being evaluated. It is important to identify the ideal patient group for treatment deintensification and to define prognostic risk groups to avoid undertreating the poorer-risk subset in HPVA-OPC, and validated biomarkers are needed to identify patients with the best prognosis. Significant smoking exposure mitigates the favorable prognosis of HPVA-OPC. Currently, less intense treatment is an option only in the setting of clinical trials, and patients with HP...Continue Reading

References

May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
May 12, 2000·Archives of Otolaryngology--head & Neck Surgery·R J SinardD E Schuller
Feb 25, 2003·The American Journal of Pathology·Jens P KlussmannPawel G Fuchs
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara BurtnessUNKNOWN Eastern Cooperative Oncology Group
Jan 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul M WeinbergerAmanda Psyrri
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robbert J C SlebosChristine H Chung
Mar 24, 2006·Journal of Medical Virology·Patrícia Rossi do SacramentoPaula Rahal
Sep 1, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Paul M WeinbergerAmanda Psyrri
Feb 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jessica H MaxwellThomas E Carey
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danny RischinGrant A McArthur
Oct 23, 2010·Advances in Anatomic Pathology·Anthony N Snow, Jennifer Laudadio
Feb 15, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M R PosnerK J Cullen
Feb 18, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zeyi DengMikio Suzuki
Mar 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eirini PectasidesAmanda Psyrri
Mar 25, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pernille LassenUNKNOWN Danish Head and Neck Cancer Group (DAHANCA)
Apr 7, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Richard J YoungBenjamin Solomon
Apr 30, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jean Lacau St GuilyFrançois Denis
Jun 4, 2011·Journal of the National Comprehensive Cancer Network : JNCCN·Erich M Sturgis, K Kian Ang
Oct 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew G SchacheRichard J Shaw
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
May 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maura L GillisonK Kian Ang
Jul 13, 2012·Head and Neck Pathology·Aldo Venuti, Francesca Paolini
Jan 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian O'SullivanWei Xu
Feb 15, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T RampiasA Psyrri
Apr 23, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Thorsten RieckmannMalte Kriegs
Apr 27, 2013·Cancer Discovery·Vivian W Y LuiJennifer R Grandis
Jun 8, 2013·Brazilian Journal of Otorhinolaryngology·Katherine QuinteroGloria I Sanchez
Jun 12, 2013·Cancer Research·Randall J KimplePaul M Harari
Nov 12, 2013·International Journal of Radiation Oncology, Biology, Physics·Shao Hui HuangJohn Waldron
Nov 14, 2013·Virology Journal·Lorena BabociMichael Pawlita
Nov 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison

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Citations

Jan 21, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Efterpi KostareliJochen Hess
Aug 18, 2016·Oral Oncology·Matthew C Ward, Shlomo A Koyfman
Jul 28, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Guoqing QianZhuo G Chen
Aug 12, 2016·International Journal of Radiation Oncology, Biology, Physics·John N Waldron, Brian O'Sullivan
Oct 19, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jacqueline R KellyBarbara Burtness
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danny RischinQuynh-Thu Le
Apr 27, 2017·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Sarah Deschuymer, Sandra Nuyts
Jun 1, 2017·The Laryngoscope·Nicole D FacompreDevraj Basu
Jun 18, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jeremy SheltonJames S Lewis
Jun 28, 2017·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Peter D CervenkaBradley Jones
Apr 21, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Shiayin F YangMichael J Zilliox
Jul 25, 2017·Head & Neck·Ryan P GoepfertKatherine A Hutcheson
Apr 11, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R I HaddadJ B Vermorken
Sep 18, 2018·Expert Review of Molecular Diagnostics·Elizabeth J Franzmann, Michael J Donovan
Oct 31, 2018·Expert Opinion on Biological Therapy·Ziena AbdulrahmanMariette Ie Van Poelgeest
Apr 3, 2019·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·P MorbiniM Benazzo
May 21, 2017·The Oncologist·James A BonnerJan B Vermorken
Jan 1, 2016·Cancers of the Head & Neck·Tim N Beck, Erica A Golemis
Jan 16, 2019·Cancer·Melina J WindonCarole Fakhry
Sep 23, 2018·Journal of Global Oncology·Ryan K Cleary, Anthony J Cmelak
Sep 27, 2019·Frontiers in Oncology·Panagiota EconomopoulouAmanda Psyrri
Oct 12, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Upendra ParvathaneniChristine M Glastonbury
Oct 27, 2020·Annals of the New York Academy of Sciences·Shanmugarajah RajendraShweta Dutta Gautam
Feb 6, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ravindra UppaluriDouglas R Adkins
Sep 16, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ilona ArgirionLaura S Rozek

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