Human papillomavirus capsids preferentially bind and infect tumor cells

International Journal of Cancer. Journal International Du Cancer
Rhonda C KinesJohn T Schiller

Abstract

We previously determined that human papillomavirus (HPV) virus-like particles (VLPs) and pseudovirions (PsV) did not, respectively, bind to or infect intact epithelium of the cervicovaginal tract. However, they strongly bound heparan sulfate proteoglycans (HSPG) on the basement membrane of disrupted epithelium and infected the keratinocytes that subsequently entered the disrupted site. We here report that HPV capsids (VLP and PsV) have the same restricted tropism for a wide variety of disrupted epithelial and mesothelial tissues, whereas intact tissues remain resistant to binding. However, the HPV capsids directly bind and infect most tumor-derived cell lines in vitro and have analogous tumor-specific properties in vivo, after local or intravenous injection, using orthotopic models for human ovarian and lung cancer, respectively. The pseudovirions also specifically infected implanted primary human ovarian tumors. Heparin and ι-carrageenan blocked binding and infection of all tumor lines tested, implying that tumor cell binding is HSPG-dependent. A survey using a panel of modified heparins indicates that N-sulfation and, to a lesser degree, O-6 sulfation of the surface HSPG on the tumors are important for HPV binding. Therefore,...Continue Reading

References

Mar 15, 2000·The International Journal of Biochemistry & Cell Biology·S TumovaJ R Couchman
Jan 11, 2001·Journal of Virology·T GiroglouM Sapp
Apr 20, 2001·International Immunology·D M Da SilvaW M Kast
Jul 18, 2001·The Journal of Clinical Investigation·J D Esko, U Lindahl
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dongfang LiuRam Sasisekharan
Mar 9, 2002·Seminars in Thrombosis and Hemostasis·Dongfang LiuRam Sasisekharan
Mar 29, 2002·Journal of Clinical Pathology·F X BoschK V Shah
Jul 3, 2002·Nature Reviews. Cancer·Ram SasisekharanUma Narayanasami
Apr 23, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Petra LenzJohn T Schiller
Dec 25, 2003·Journal of Virology·Christopher B BuckJohn T Schiller
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sohrab BodaghiZhi-Ming Zheng
Aug 3, 2005·Nature Reviews. Cancer·Mark M Fuster, Jeffrey D Esko
Oct 14, 2005·British Journal of Cancer·C-Y KanN J Whitaker
Nov 8, 2005·Journal of Clinical Microbiology·Sohrab BodaghiZhi-Ming Zheng
Jul 15, 2006·PLoS Pathogens·Christopher B BuckJohn T Schiller
Jul 21, 2007·The Journal of Biological Chemistry·Maren KnappeMartin Sapp
Oct 12, 2007·Journal of Virology·Ratish GambhiraRichard B S Roden
Jan 30, 2008·Current Protocols in Cell Biology·Christopher B Buck, Cynthia D Thompson
Jul 17, 2008·Nature Reviews. Molecular Cell Biology·Matthias Schäfer, Sabine Werner
Aug 22, 2009·Journal of Medical Virology·Alice Che-Ha ChenAnnika Antonsson
Nov 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rhonda C KinesPatricia M Day
Jun 26, 2010·BMC Cancer·Margarita L Martinez-FierroAugusto Rojas-Martinez
Sep 3, 2010·Progress in Molecular Biology and Translational Science·Mark M Fuster, Lianchun Wang
Nov 13, 2012·The Journal of Clinical Investigation·Nicolas ÇuburuJohn T Schiller
Feb 26, 2013·Journal of Internal Medicine·U Lindahl, L Kjellén
Jul 31, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D C DaminA P Damin
Aug 27, 2013·Lancet·Martin ReckKlaus F Rabe
Apr 29, 2014·Lancet·Gordon C JaysonJonathan A Ledermann
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Dec 3, 2014·La Presse médicale·Rosita Accardi, Tarik Gheit

❮ Previous
Next ❯

Citations

Feb 18, 2017·Genetics and Molecular Biology·Rodrigo Pinheiro AraldiWilly Beçak
Jul 20, 2016·International Journal of Molecular Sciences·Rim HojeijDenise Nardelli-Haefliger
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Kimberly M KomatsubaraAxel Hauschild
Sep 6, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Edward P Rybicki
Mar 4, 2020·Cancers·Sudipta PathakEdyta Paradowska
Apr 23, 2020·Advances in Wound Care·Muhammad BilalHafiz M N Iqbal
Sep 25, 2020·Scientific Reports·Timra D GilsonElliot J Androphy
Dec 16, 2017·Molecular Cancer Therapeutics·Rhonda C KinesJohn T Schiller
Oct 30, 2020·OncoTargets and Therapy·Yan HuFenglei Yu
Feb 20, 2021·Current Opinion in Ophthalmology·Timothy T XuLauren A Dalvin
Jan 13, 2021·Sexually Transmitted Diseases·Cassandra LaurieEduardo L Franco
Jul 3, 2021·Biology·Muhammad Nur Adam HattaHui-Min Neoh
Aug 22, 2021·Cardiovascular Research·Amanda J ChaseJoseph C Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.