Abstract
Head and neck squamous cell carcinoma (HNSCC) is the one of the most frequently found cancers in the world. The aim of the study was to find the genes responsible and enriched pathways associated with HNSCC using bioinformatics and survival analysis methods. A total of 646 patients with HNSCC based on clinical information were considered for the study. HNSCC samples were grouped according to the parameters (RFS, DFS, PFS, or OS). The probe ID of these 11 genes was retrieved by Affymetrix using the NetAffx Query algorithm. The protein-protein interaction (PPI) network and Kaplan-Meier curve were used to find associations among the genes' expression data. We found that among these 11 genes, nine genes, CCNA1, MMP3, FLRT3, GJB6, ZFR2, PITX2, SYCP2, MEI1, and UGT8 were significant (p < .05). A survival plot was drawn between the p value and gene expression. This study helped us find the nine significant genes which play vital roles in HNSCC along with their key pathways and their interaction with other genes in the PPI network. Finally, we found the biomarker index for relapse time and risk factors for HNSCC in cancer patients.
References
Mar 31, 2000·BMJ : British Medical Journal·H O Dickinson
May 18, 2001·Oral Diseases·B Birkedal-HansenW G Stetler-Stevenson
May 14, 2004·The Journal of Investigative Dermatology·Shuichi TsuchidaKiyoshi Ariizumi
Apr 15, 2005·Oncogene·Ping JiCarsten Müller-Tidow
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gary M CliffordJeanne M Pimenta
Nov 3, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ivan MartinezSaleem A Khan
May 19, 2007·Cancer Research·Dohun PyeonPaul Ahlquist
Sep 18, 2008·Cancer Investigation·Zhang ZhuangZhao Hongwei
Mar 23, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Angela StokesVeli-Matti Kähäri
May 27, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Maureen A SartorLaura S Rozek
Oct 3, 2012·PloS One·Kavita M PattaniJoseph A Califano
Oct 16, 2013·International Journal of Cancer. Journal International Du Cancer·Jeroen J MoorenJens P Klussmann
Jan 17, 2015·Oncoscience·Kelsie L ThuMing-Sound Tsao
Aug 8, 2015·Cancer Science·Kanwalat ChalertpetPattamawadee Yanatatsaneejit
Oct 5, 2016·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Ernst Jan M Speel
Oct 8, 2016·Oncotarget·Verena SailerDimo Dietrich
Jan 7, 2017·BMC Infectious Diseases·Rashmirani SenapatiBhagirathi Dwibedi
Jan 20, 2017·Oncology Letters·Maria J WorshamGeorge Divine
Jun 16, 2017·PloS One·Verena SailerDimo Dietrich
May 8, 2018·The Journal of Experimental Medicine·Qianhua CaoChenfang Dong
Oct 17, 2018·Scientific Reports·Raquel L CostaMarcelo A Soares