Human Papillomavirus Genotype Distribution among Cervical Cancer Patients prior to Brazilian National HPV Immunization Program

Journal of Environmental and Public Health
Liz M de AlmeidaMiguel Angelo M Moreira

Abstract

To evaluate the impact of HPV immunization and possible changes in virus type-specific prevalence associated with cervical cancer, it is important to obtain baseline information based on socioeconomic, educational, and environmental characteristics in human populations. We describe these characteristics and the type-specific HPV distribution in 1,183 women diagnosed with cervical cancer in two Brazilian healthcare institutions located at the Southeastern (Rio de Janeiro/RJ) and the Amazonian (Belém/PA) regions. Large differences were observed between women in these regions regarding economic, educational, and reproductive characteristics. The eight most frequent HPV types found in tumor samples were the following: 16, 18, 31, 33, 35, 45, 52, and 58. Some HPV types classified as unknown or low risk were found in tumor samples with single infections, HPV 83 in RJ and HPV 11, 61, and 69 in PA. The proportion of squamous cervical cancer was lower in RJ than in PA (76.3% versus 87.3%, p < 0.001). Adenocarcinoma was more frequent in RJ than in PA (13.5% versus 6.9%, p < 0.001). The frequency of HPV 16 in PA was higher in younger women (p < 0.05). The success of a cervical cancer control program should consider HPV types, local health...Continue Reading

References

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Citations

Jun 10, 2017·Archives of Virology·Diogo Lisbôa BastoMiguel Ângelo Martins Moreira
Oct 3, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Valéria B PontesLiz Maria de Almeida
Nov 8, 2019·Journal of Medical Virology·Diogo Lisbôa BastoMiguel Ângelo Martins Moreira
Nov 30, 2018·World Journal of Gastroenterology : WJG·Carolina Rosal Teixeira de SouzaRommel Mario Rodríguez Burbano
Apr 10, 2019·International Journal of Cancer. Journal International Du Cancer·Sergio M Amaro-FilhoRobert D Burk
Apr 11, 2021·International Journal of Cancer. Journal International Du Cancer·Christer BorgfeldtOla Forslund

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Methods Mentioned

BETA
biopsy
biopsies
PCR
Genotyping

Software Mentioned

Epi
Info
Blast

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