Human papillomavirus (HPV) perinatal transmission and risk of HPV persistence among children: Design, methods and preliminary results of the HERITAGE study

Papillomavirus Research
Helen TrottierFrançois Audibert

Abstract

Perinatal route of transmission of human papillomavirus (HPV) has been demonstrated in several small studies. We designed a large prospective cohort study (HERITAGE) to better understand perinatal HPV. The objective of this article is to present the study design and preliminary data. In the first phase of the study, we recruited 167 women in Montreal, Canada, during the first trimester of pregnancy. An additional 850 are currently being recruited in the ongoing phase. Cervicovaginal samples were obtained from mothers in the first trimester and tested for HPV DNA from 36 mucosal genotypes (and repeated in the third trimester for HPV-positive mothers). Placental samples were also taken for HPV DNA testing. Conjunctival, oral, pharyngeal and genital samples were collected for HPV DNA testing in children of HPV-positive mothers at every 3-6 months from birth until 2 years of age. Blood samples were collected in mother and children for HPV serology testing. We found a high prevalence of HPV in pregnant women (45%[95%CI:37-53%]) and in placentas (14%[8-21%]). The proportion of HPV positivity (any site) among children at birth/3-months was 11%[5-22%]. HPV was detected in children in multiple sites including the conjunctiva (5%[10-14%]...Continue Reading

Citations

Sep 5, 2018·European Journal of Oral Sciences·Stina Syrjänen
Apr 24, 2019·Current Treatment Options in Oncology·Jessica D McDermott, Daniel W Bowles
Nov 11, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Αikaterini K ChalkiaΕfstathios T Detorakis
Aug 31, 2019·Epidemiology and Infection·Reyna Lizette Pacheco-DomínguezMalaquías López-Cervantes
Nov 7, 2019·BMC Infectious Diseases·Mariusz SkoczyńskiAnna Kwaśniewska
Jan 30, 2021·Emerging Infectious Diseases·Stina SyrjänenKarolina Louvanto
Jun 8, 2021·Curēus·Mihaela C RaduCorneliu Zaharia
Jul 26, 2021·Indian Journal of Ophthalmology·Geeta K Vemuganti
Aug 29, 2021·Viruses·Ingvild Ramberg, Steffen Heegaard
Sep 16, 2021·JAMA Network Open·Joseph NiyibiziUNKNOWN HERITAGE Study Group
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rodrigo Pinheiro AraldiEdislane Barreiros de Souza

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Methods Mentioned

BETA
biopsies
biopsy
genotyping

Software Mentioned

HERITAGE
BIOPSY

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