PMID: 16525675Mar 10, 2006Paper

Human papillomavirus in lung carcinomas among three Latin American countries

Oncology Reports
A CastilloY Eizuru

Abstract

The presence of human papillomavirus (HPV) genome in lung carcinomas has been reported worldwide but its frequency varies from country to country. We examined HPV genome in 36 lung carcinomas, consisting of 14 squamous cell carcinomas, 13 adenocarcinomas, and 9 small cell carcinomas, collected from Colombia, Mexico and Peru. PCR analysis using GP5+/GP6+ primers, combined with Southern blot hybridization, found the presence of HPV genome in 10 (28%) of 36 cases. This percentage is similar to the value of 22% reported by Syrjänen, who conducted a meta-analysis of nearly 2500 lung carcinomas examined to date. Genotype analysis revealed that the most predominant genotype was HPV-16 (7 cases), followed by HPV-18 (2 cases) and HPV-33 (1 case). HPV-16 was more frequently found among female than male cases (P=0.008) but was not detected in any adenocarcinoma cases. On the other hand, HPV-18 and HPV-33 were detected only among male cases. These HPV genotypes were detected only in adenocarcinomas, and all the HPV genotypes detected in this histological type were HPV-18 or HPV-33. The frequency of HPV-16 positive cases among all the HPV positive cases differed in the sexes (P=0.033) and differed in the three histological types (P=0.017). ...Continue Reading

Citations

Jul 20, 2010·Pathology Oncology Research : POR·Ioannis N MammasDemetrios A Spandidos
Jul 14, 2009·The American Journal of the Medical Sciences·Arash RezazadehGoetz Kloecker
Dec 14, 2011·Pathology, Research and Practice·Waleed F M Amin Kotb, Iver Petersen
Sep 21, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·D KrikelisS Kouidou
Sep 10, 2010·Cancer Letters·Marco G PaggiWalter Malorni
Nov 21, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Friederike KleinIver Petersen
Sep 4, 2007·Trends in Endocrinology and Metabolism : TEM·Michelle A CareyDarryl C Zeldin
Feb 11, 2015·Human Pathology·Christopher P HartleyLaura J Tafe
Jul 4, 2009·World Journal of Gastroenterology : WJG·Roberto Herrera-GoepfertMauricio Becker-D'Acosta

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