Human papillomavirus infection and esophageal squamous cell carcinoma: a case-control study.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Fangcen GuoYang Ke

Abstract

The risk factors for esophageal squamous cell carcinoma (ESCC) in the high-incidence areas of China remain unclear. A total of 300 patients with ESCC and 900 controls matched for age and sex were enrolled in Anyang (China), a high-risk area for ESCC in China. In tumor tissue of the cases and in esophageal biopsies of controls, the presence of human papillomavirus (HPV) DNA was assessed by an SPF1/GP6(+)-mediated PCR followed by sequencing. The presence of serum antibody against the HPV-16 E7 oncoprotein was assessed by use of the ELISA. ORs with 95% confidence intervals (CI) were calculated via unconditional logistic regression models. The presence of HPV in the esophagus (OR, 6.4; 95% CI, 4.4-9.2) was associated with increased risk of ESCC. Moreover, infection with "oncogenic" types of HPV (OR, 10.3; 95% CI, 6.3-16.8) was more strongly associated with ESCC than other types of HPV (OR, 2.4; 95% CI, 1.4-4.2). The presence of HPV-16 (OR, 12.8; 95% CI, 7.6-21.7) was particularly strongly associated with ESCC. In addition, a higher proportion of cases than controls had serum antibodies against HPV-16 E7 (OR, 6.1; 95% CI, 3.7-10.0). This study provides the strongest epidemiologic evidence to date in support of the important role of ...Continue Reading

References

Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T C KokJ T Ter Schegget
Apr 3, 1999·International Journal of Cancer. Journal International Du Cancer·E M de VilliersS Syrjänen
Nov 15, 2000·Cancer Causes & Control : CCC·X CastellsaguéP A Rolón
Sep 13, 2002·Journal of Medical Virology·Zhong-Ying ShenYi Zeng
Oct 2, 2002·Journal of Clinical Pathology·K J Syrjänen
Nov 7, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A M KamathK V Shah
Jun 9, 2004·Virology·Ethel-Michele de VilliersHarald zur Hausen
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Gina D TranPhilip R Taylor
Apr 16, 2005·The Lancet Oncology·Vincent CoglianoUNKNOWN WHO International Agency for Research on Cancer
Feb 24, 2006·International Journal of Cancer. Journal International Du Cancer·Farin KamangarSteven D Mark
Sep 7, 2006·Journal of Clinical Microbiology·Dennis van HamontWillem J G Melchers
Sep 11, 2007·Lancet·Mark SchiffmanSholom Wacholder
Feb 14, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J S KohY I Kim
Nov 18, 2009·International Journal of Cancer. Journal International Du Cancer·Jill KoshiolSanford M Dawsey
Dec 7, 2010·International Journal of Hygiene and Environmental Health·Qing-Ying ZhangWilliam W Au

❮ Previous
Next ❯

Citations

Jan 24, 2016·Chinese Journal of Cancer·Ying ShiYa Cao
Oct 1, 2014·Annals of the New York Academy of Sciences·Sahar Al-HaddadBin Wang
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Shao-Kai ZhangXi-Bin Sun
Apr 28, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HoebenJ de Vos-Geelen
Feb 18, 2017·Genetics and Molecular Biology·Rodrigo Pinheiro AraldiWilly Beçak
Mar 28, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mengfei LiuYang Ke
Feb 15, 2018·International Journal of Molecular Sciences·Anja Lidwina GeßnerMatthias Dürst
Jun 20, 2019·American Journal of Clinical Pathology·Edward B StelowVanessa M Shami
Dec 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Shahab MahmoudvandJamal Sarvari
Aug 1, 2019·International Journal of Oncology·Yu LiuXiaorong Qi
Oct 30, 2016·The International Journal of Biological Markers·Wen-Jie WangHui-Fang Wu
Apr 4, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Philip R TaylorSanford M Dawsey
Sep 14, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mengfei LiuYang Ke
Oct 31, 2020·Oxidative Medicine and Cellular Longevity·Ying ZhangLihong Yin
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rodrigo Pinheiro AraldiEdislane Barreiros de Souza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Min DaiSilvia Franceschi
World Journal of Gastroenterology : WJG
Roberto Herrera-GoepfertMauricio Becker-D'Acosta
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Maria Lina TorneselloFranco Maria Buonaguro
© 2022 Meta ULC. All rights reserved