Human Papillomavirus Infections, Cervical Cancer and MicroRNAs: An Overview and Implications for Public Health.

Michela Lucia SammarcoGiancarlo Ripabelli


Human Papillomavirus (HPV) is among the most common sexually transmitted infections in both females and males across the world that generally do not cause symptoms and are characterized by high rates of clearance. Persistent infections due at least to twelve well-recognized High-Risk (HR) or oncogenic genotypes, although less frequent, can occur, leading to diseases and malignancies, principally cervical cancer. Three vaccination strategies are currently available for preventing certain HR HPVs-associated diseases, infections due to HPV6 and HPV11 low-risk types, as well as for providing cross-protection against non-vaccine genotypes. Nevertheless, the limited vaccine coverage hampers reducing the burden of HPV-related diseases globally. For HR HPV types, especially HPV16 and HPV18, the E6 and E7 oncoproteins are needed for cancer development. As for other tumors, even in cervical cancer, non-coding microRNAs (miRNAs) are involved in posttranscriptional regulation, resulting in aberrant expression profiles. In this study, we provide a summary of the epidemiological background for HPV occurrence and available immunization programs. In addition, we present an overview of the most relevant evidence of miRNAs deregulation in cervic...Continue Reading


Jan 26, 2005·Current Biology : CB·Yukihide Tomari, Phillip D Zamore
May 26, 2005·Virology·Mark SchiffmanRobert D Burk
Aug 4, 2006·Cancer Research·George Adrian Calin, Carlo Maria Croce
Jul 10, 2007·Cancer Research·Weng-Onn LuiAndrew Fire
Jan 4, 2008·Cancer Research·Svetlana VinokurovaMagnus von Knebel Doeberitz
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeong-Won LeeDuk-Soo Bae
Nov 15, 2008·Virology·Margaret E McLaughlin-Drubin, Karl Münger
Jul 14, 2009·The Journal of Pathology·Raffaele BaffaAnne Rosenberg
Feb 13, 2010·The Journal of Obstetrics and Gynaecology Research·YanLiang ZhangChengxiao Hu
May 11, 2010·The Lancet Oncology·Shanthi MarurArlene A Forastiere
Jul 30, 2010·PloS One·Patrícia M PereiraManuel A S Santos
Aug 27, 2010·Trends in Microbiology·Ignacio G BravoMarc Gottschling
Jan 11, 2011·The International Journal of Biochemistry & Cell Biology·Ran QiangHua Tang
Jan 26, 2011·Medical Oncology·Qunxian RaoZhongqiu Lin
Jun 4, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Bao Hua LiXing Xie
Oct 18, 2011·Biochimica Et Biophysica Acta·Tingting Yao, Zhongqiu Lin
Jan 6, 2012·Cancer Prevention Research·Douglas R Lowy, John T Schiller
Jul 18, 2012·Cell Cycle·Tak-hong CheungYick-fu Wong
Sep 19, 2012·Genes, Chromosomes & Cancer·Mariska BierkensRenske D M Steenbergen
Nov 20, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Fang CuiHong Shi
Feb 12, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Michela L SammarcoGiancarlo Ripabelli
May 30, 2013·Experimental and Molecular Pathology·Ai-Yan XingPeng Gao

❮ Previous
Next ❯


Aug 28, 2021·International Journal of Molecular Sciences·Georgiana DrețcanuZorița Diaconeasa
Aug 29, 2021·Molecular and Cellular Biochemistry·Tandrima Mitra, Selvakumar Elangovan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Chih-Hsiang ChangGuang-Yuh Hwang
Mayo Clinic Proceedings
Christine M Huang
Current Problems in Cancer
Jessica St LaurentSarah Feldman
© 2021 Meta ULC. All rights reserved