Human papillomavirus is not associated to non-small cell lung cancer: data from a prospective cross-sectional study

Infectious Agents and Cancer
Estela Maria SilvaAdhemar Longatto-Filho

Abstract

The pathogenesis of lung cancer is triggered by a combination of genetic and environmental factors, being the tobacco smoke the most important risk factor. Nevertheless, the incidence of lung cancer in non-smokers is gradually increasing, which demands the search for different other etiological factors such as occupational exposure, previous lung disease, diet among others. In the early 80's a theory linked specific types of human papillomavirus (HPV) to lung cancer due to morphological similarities of a subset of bronchial squamous cell carcinomas with other HPV-induced cancers. Since then, several studies revealed variable rates of HPV DNA detection. The current study aimed to provide accurate information on the prevalence of HPV DNA in lung cancer. Biopsies were collected from 77 newly diagnosed non-small cell lung cancer (NSCLC) patients treated at the Thoracic Oncology Department at Barretos Cancer Hospital. The samples were formalin fixed and paraffin embedded (FFPE), histologic analysis was performed by an experienced pathologist. DNA was extracted from FFPE material using a commercial extraction kit and HPV DNA detection was evaluated by multiplex PCR and HPV16 specific real-time PCR. HPV was not identified in any of th...Continue Reading

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Citations

Oct 30, 2020·OncoTargets and Therapy·Yan HuFenglei Yu
Feb 25, 2021·Cancer Reports·Julia KarnoskyChristian Schulz
Jun 4, 2021·Frontiers in Medicine·Vianey Rodriguez-Lara, Maria Rosa Avila-Costa

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Methods Mentioned

BETA
PCR
biopsies
genotyping

Software Mentioned

Ovid
MEDLINE
SPSS® Statistics
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