Human papillomavirus load in benign HPV-associated oral lesions from HIV/AIDS individuals

Oral Diseases
S Camacho-AguilarGabriela Anaya-Saavedra

Abstract

Although HPV emerged as a crucial carcinogenic and prognostic biomarker in head and neck cancer, and considering the increase in HPV-associated oral lesions (HPV-OLs) in HIV individuals, molecular information about HPV-OLs is scarce; thus, our aim was to determine viral loads in HPV-OLs from HIV/AIDS individuals. HIV/AIDS subjects with HPV-OL were included in this cross-sectional study. Following informed consent, biopsies were obtained. HPV detection and typing were carried out by PCR and sequencing (MY09/11, GP5+/6+). HPV-13 and HPV-32 loads were determined by a high-resolution melting assay. For statistical analysis, X2 , Fisher's exact, and Mann-Whitney U tests were applied, using SPSS software (v.23). Twenty-nine HIV subjects (median age 38 years, 93% males) were included. Most were AIDS individuals (72.4%) under HAART (89.7%). Twenty-two (75.9%) participants had more than one HPV-OL (four with florid presentations), mostly multifocal epithelial hyperplasia (62%), being HPV-13 (26%) and HPV-32 (31%) the most frequent types. HPV load was higher in individuals with multiple HPV-OLs than in solitary lesions (4.9 vs. 3.2 Log10 copies/ml, p = .090) and in HPV-32+ than in HPV-13+ (8.3 vs. 6.4 Log10 copies/ml, p = .014). Multiple...Continue Reading

References

Aug 16, 2003·Medical Microbiology and Immunology·Stina Syrjänen
Mar 24, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Lorena BaccagliniDouglas E Peterson
Jan 3, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gabriela Anaya-SaavedraVelia Ramírez-Amador
Mar 23, 2013·Oral Diseases·L L PattonK Ranganathan
Jan 2, 2015·Therapeutic Advances in Vaccines·Paolo BonanniSara Boccalini
Feb 11, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shao Hui HuangBrian O'Sullivan
Jan 29, 2016·Scientific Reports·Lynda GrineClaude Libert
Jun 30, 2016·The New England Journal of Medicine·Jacobo Limeres Posse, Crispian Scully

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Citations

Sep 5, 2018·European Journal of Oral Sciences·Stina Syrjänen
Oct 17, 2019·Revista Do Instituto De Medicina Tropical De São Paulo·Daniela Assis do ValeKarem López Ortega
Nov 17, 2019·Oral Diseases·Stefano Petti, Giovanni Lodi
Aug 29, 2021·Viruses·Simone Kloch BendtsenChristian von Buchwald

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