Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: human papillomavirus-mediated carcinogenesis.

Head & Face Medicine
Liviu FellerJohan Lemmer

Abstract

High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.

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Citations

Mar 14, 2013·Clinical Oral Investigations·Camila Maria Beder RibeiroJair Carneiro Leao
Sep 11, 2013·Veterinary Microbiology·Lubna Nasir, Sabine Brandt
Dec 23, 2015·Archives of Oral Biology·Uzma Urooj MalikStephen R Pennington
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Aug 24, 2012·Critical Reviews in Clinical Laboratory Sciences·Paul K S ChanJong Sup Park
Aug 16, 2017·Journal of Experimental & Clinical Cancer Research : CR·Hai-Long MaLai-Ping Zhong

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Methods Mentioned

BETA
acetylation
biopsy

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