Abstract
Human papillomavirus (HPV) infection is associated with multiple types of cancer, but the evidence has not yet been fully elucidated in bladder cancer. Frozen tissue samples collected from 146 patients aged 32 to 89 years with bladder cancer pathological diagnosis between 2015 and 2019 were analyzed. HPV genotyping and integration status determination were performed by capture-based next generation sequencing. Statistical analysis of HPV type distributions was performed according to stage, grade, sex, and age group of patients. Mean (SD) age of the 146 patients was 66.64 ± 10.06 years and 83.56% were men. Overall HPV infection rate was 28.77% (37.50% in women and 27.05% in men), with 11.90% HPV integration events. Among them, 17.12% single and 11.65% coinfections were observed. HPV18 (24.66%) was the most prevalent genotype, followed by HPV33, 16, and 39. All HPV were European lineage (A). HPV16 was more prevalent in women (P = .04). HPV infection may contribute to the etiology both in men and women with bladder cancer. HPV18, followed by HPV33, 16, and 39 genotypes, potentially represent the predominant oncogenic risk types for bladder carcinogenesis.
References
Mar 1, 2007·JAMA : the Journal of the American Medical Association·Eileen F DunneLauri E Markowitz
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Apr 12, 2011·Nature Genetics·Mark A DePristoMark J Daly
May 31, 2013·Head & Neck·Heath D SkinnerBeth M Beadle
Sep 4, 2013·Virology·Robert D BurkZigui Chen
Jan 31, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Oct 2, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kazuyoshi ShigeharaMikio Namiki
Nov 8, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuyoshi Shigehara, Mikio Namiki
Apr 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Sivalingam NalliahKumaraswamy Kademane
Jan 24, 2017·JAMA Oncology·Jasmine J HanY Sammy Choi
Feb 27, 2017·Head & Neck·Heather M WallineUNKNOWN University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE) Program
May 23, 2017·Mutation Research. Reviews in Mutation Research·Mallory E Harden, Karl Munger
May 23, 2017·Mutation Research. Reviews in Mutation Research·Julia DurzynskaElzbieta Poreba
Sep 9, 2017·Cell·Lisa MirabelloMark Schiffman
Sep 21, 2017·Molecular Cancer Research : MCR·Lada A KonevaMaureen A Sartor
Nov 7, 2017·Virology·Paul G CantalupoJames M Pipas
Mar 16, 2016·NPJ Genomic Medicine·Allyson HolmesAlain Nicolas
Feb 14, 2018·Viruses·Lisa MirabelloRobert D Burk
Jul 8, 2018·Journal of Infection and Public Health·Joanna Krzowska-FirychŁukasz Pietrzyk
Jul 26, 2018·Current Problems in Cancer·Jessica St LaurentSarah Feldman
Jul 28, 2018·Scientific Reports·Matthew A LlewellynRichard T Bryan
Sep 13, 2018·CA: a Cancer Journal for Clinicians·Freddie BrayAhmedin Jemal
Jan 27, 2019·Scientific Reports·Sonja LagströmTrine B Rounge
Mar 16, 2019·Genome Research·Xun ChenDawei Li
Mar 22, 2019·BMC Genomics·Tengguo LiMangalathu S Rajeevan
Jun 4, 2019·Cancer Epidemiology·Haitham MirghaniValérie Costes-Martineau
Jun 19, 2019·Nature Genetics·Miao XuJianjun Liu
Jul 31, 2019·JNCI Cancer Spectrum·Silvia de SanjoséUNKNOWN RIS HPV TT, VVAP and Head and Neck study groups
Oct 19, 2019·International Journal for Equity in Health·Daniel GraceIrving E Salit
Nov 27, 2019·Cancers·Adeline MorelWulfran Cacheux
Dec 11, 2019·American Journal of Clinical Pathology·Meng CaoHongwei Chen
Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kit Riegels Jørgensen, Jørgen Bjerggaard Jensen