Human papillomavirus prevalence and type distribution in 3603 HIV-positive and HIV-negative women in the general population of Tanzania: the PROTECT study

Sexually Transmitted Diseases
Myassa DartellSusanne Krüger Kjaer

Abstract

The aim of the Prevention of Cervical Cancer in Tanzania (PROTECT) study is to assess the prevalence of oncogenic human papillomavirus (HPV) and to determine the type distribution among women in the general population according to human immunodeficiency virus (HIV) status, in preparation for a potential HPV immunization program. We included 3603 women from the general population in urban and rural areas of Tanzania. All women underwent a gynecological examination where a Pap smear was obtained and cervical cells were collected to assess the presence of high-risk (HR) HPV DNA by hybrid capture 2 test. Genotyping was performed by the LiPaExtra method. These women were also tested for HIV. The prevalence of HR HPV types was 20.1%, ranging from 14.8% in women with normal cytology to 94.2% in women with high grade squamous intraepithelial lesion (HSIL) or worse (100% in 5 cancers). In women with normal cytology or low-grade lesions, the most common type was HPV52 (3.2%), followed by HPV16 (2.1%). In contrast, HPV16 was the dominating type in HSIL or worse (32.8%). No cancers contained HPV52. The HR HPV prevalence was higher in HIV-positive women (46.7%) than in HIV-negative women (17.2%). No specific HR HPV types were significantly ...Continue Reading

References


❮ Previous
Next ❯

Citations

Apr 18, 2014·The Journal of Infectious Diseases·Catherine F HoulihanDeborah Watson-Jones
May 9, 2014·Sexually Transmitted Infections·Tina Bech OlesenSusanne K Kjaer
Mar 15, 2013·Sexually Transmitted Infections·Deborah Watson-JonesSilvia de Sanjosé
Jan 17, 2014·Journal of Korean Medical Science·Eun Kyoung ParkIhm Soo Kwak
Apr 19, 2017·International Journal of Epidemiology·Sally N AdebamowoUNKNOWN ACCME Research Group as part of the H3Africa Consortium
Jul 6, 2016·Women & Health·Mette Tuxen FaberSusanne K Kjaer
Jan 7, 2014·International Journal of Cancer. Journal International Du Cancer·Myassa Arkam DartellSusanne Kruger Kjaer
Nov 18, 2018·Tropical Medicine & International Health : TM & IH·Birgitte Baldur-FelskovSusanne K Kjaer
Oct 10, 2018·Journal of Medical Microbiology·Haddy Bah CamaraPatrick T Kimmitt
Jan 18, 2020·International Journal of STD & AIDS·Kristen SweetJennifer S Smith
Aug 21, 2013·Sexually Transmitted Diseases·Myassa DartellSusanne Krüger Kjaer
Nov 11, 2016·AIDS·Aysel GuelerUNKNOWN Swiss HIV Cohort Study, Swiss National Cohort
Mar 6, 2016·International Journal of Epidemiology·Catherine F HoulihanDeborah Watson-Jones
Aug 24, 2013·Sexually Transmitted Diseases·Tina Bech OlesenSusanne Krüger Kjaer
Jun 29, 2018·AIDS·Pragna PatelUNKNOWN NIH HIV/NCD Project Disease Condition Technical Operating Group
Jul 24, 2013·Cancer Prevention Research·Fang-Hui ZhaoPhilip E Castle
Aug 29, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Armando BaenaNathalie Broutet
Jul 17, 2019·Gynecologic Oncology Reports·Ava S RungeKrishnansu S Tewari
Aug 26, 2021·BMC Cancer·Guanglei ZhongTingting Yao

❮ Previous
Next ❯

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.