Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis.

Oral Diseases
Cecilie D de la CourSusanne K Kjaer

Abstract

We aimed to provide pooled estimates of human papillomavirus (HPV) prevalence in oral potentially malignant disorders (OPMD) and evaluate the impact of presence of epithelial dysplasia. We searched PubMed, Embase, and Cochrane Library databases for studies that examined the prevalence of HPV DNA in OPMD tested by polymerase chain reaction (PCR). Across 52 eligible studies (2,677 cases), we found an overall pooled HPV prevalence of 22.5% (95% confidence interval [CI] 16.6-29.0). Between-study heterogeneity was 93%. When stratified by subgroup, the pooled HPV prevalence in leukoplakia (1,232 cases) was 20.2% (95% CI 11.2-31.1), lichen planus (767 cases) 23.0% (95% CI 15.0-32.2), oral submucous fibrosis (238 cases) 28.6% (95% CI 23.0-34.5), proliferative verrucous leukoplakia (60 cases) 24.7% (95% CI 1.8-62.0), and OPMD unspecified (377 cases) 25.4% (95% CI 16.2-35.8). Information on presence of epithelial dysplasia was available in 19 studies, and the results did not vary substantially between non-dysplastic and dysplastic samples. HPV16 was the predominant genotype among HPV-positive OPMD cases (48.2%, 95% CI 31.4-65.2). We found a pooled HPV DNA prevalence of 22.5% in OPMD cases with great between-study heterogeneity. The HPV p...Continue Reading

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Citations

Jul 28, 2020·International Journal of Molecular Sciences·Lucía Melguizo-RodríguezRebeca Illescas-Montes
Sep 24, 2020·International Journal of Molecular Sciences·Roberto GrigolatoLorenzo Lo Muzio
Mar 9, 2021·Expert Review of Molecular Diagnostics·Kenneth P H PritzkerDavid Mock
Jul 3, 2021·International Journal of Environmental Research and Public Health·Vladimíra RadochováRadovan Slezák
Jun 29, 2021·Journal of Medical Virology·Farideh AghaeipourHamid Abbaszadeh

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