Human Papillomavirus-Related Head and Neck Cancer

Oncology Research and Treatment
Steffen WagnerJens Peter Klussmann

Abstract

Human papillomavirus(HPV)-related head and neck cancer is recognized as a distinct tumor entity with rising incidence reported for several countries. These tumors arise from squamous cells, typically in the oropharynx. In contrast to cancer associated with other risk factors, HPV-related cancer is driven by viral oncoprotein activity and has individual profiles regarding protein expression, and genetic and epigenetic alterations. Molecular characteristics are p16IN4A overexpression, absence of p53 inactivating mutations, and PI3K/AKT and Wnt pathway modulation. Patients with HPV-related head and neck cancer have improved survival compared to those with HPV-negative tumors, and p16INK4A staining has been introduced into tumor staging recently. However, no specific or toxicity-reduced treatment modalities have been established for this entity so far. Although the still incomplete and partially inconsistent data in this field needs further study, particular features of HPV-related cancers such as specific microRNA expression, immunology, or gene methylation patterns certainly have the potential to be implemented in future diagnostic and therapeutic concepts.

Citations

Sep 7, 2018·Laryngoscope Investigative Otolaryngology·Si-Young KiesslingSandro Johannes Stoeckli
Nov 12, 2019·British Journal of Cancer·Maria Elisa Sabatini, Susanna Chiocca
Apr 24, 2020·Systematic Reviews·Kabelo Matjie Bridget LekoaneThemba G Ginindza
Mar 16, 2019·Infectious Agents and Cancer·Asanori KiyunaAkira Ganaha
Oct 15, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Edward OdellCesare Piazza
Oct 16, 2020·Briefings in Bioinformatics·Rui TianZheng Hu
Dec 21, 2021·The Korean Journal of Internal Medicine·Eun Joo KangHwan Jung Yun

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