Human Papillomavirus-Related Malignancies in the Setting of Posttransplantation Immunosuppression

Archives of Pathology & Laboratory Medicine
Brittany N StiebingJeffrey A Vos

Abstract

- The use of immunosuppression to avoid allograft rejection within the host creates the opportunity for unchecked development of malignancy in the posttransplantation setting. These malignancies frequently show association with human papillomavirus. Within this specific patient population, understanding the oncogenic role of this virus is vital for prompt recognition and treatment of malignancy and precursor lesions as well as the institution of appropriate preventive measures. - To review the role of human papillomavirus in the development of malignancies and their precursor lesions in the posttransplantation setting. - The study comprised a review of the literature. - The development of human papillomavirus-related malignancies in transplantation patients is dependent on several factors, such as virus subtype, length of immunosuppression, and type of immunosuppressive therapy. Malignancies within these patients differ from those in the general population in terms of pathogenesis, frequency, and recurrence rate, and therefore require further understanding to allow for optimal surveillance and clinical management.

References

May 16, 2000·Advances in Experimental Medicine and Biology·V J TannochL H Tsai
Jun 5, 2002·Nature Reviews. Cancer·Harald zur Hausen
Apr 1, 2005·The New England Journal of Medicine·Jacques Dantal, Jean-Paul Soulillou
Sep 17, 2005·Science·Peter O'DonovanPeter Karran
Feb 1, 2006·The British Journal of Dermatology·F J MoloneyG M Murphy
Feb 24, 2006·American Journal of Clinical Dermatology·Hiok-Hee Tan, Chee-Leok Goh
Jan 2, 2007·Apoptosis : an International Journal on Programmed Cell Death·Sabrina LeverrierAlan Storey
Dec 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Andreas GaumannEdward K Geissler
Feb 23, 2010·Lancet·Vishal MadanRolf-Markus Szeimies
Jul 2, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C M ProbyUNKNOWN EPI-HPV-UV-CA group
Jul 28, 2011·Medical Microbiology and Immunology·Sönke WeissenbornUNKNOWN EPI-HPV-UV-CA group
Oct 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M M MadeleineE A Engels
Apr 2, 2015·The British Journal of Dermatology·R E Genders, J N Bouwes Bavinck

❮ Previous
Next ❯

Citations

May 23, 2019·Human Vaccines & Immunotherapeutics·Yan Geng, Liyan Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Journal of the American Society of Nephrology : CJASN
Darshika ChhabraLorenzo Gallon
European Journal of Gynaecological Oncology
C Di Berardino, G Mascaretti
The New England Journal of Medicine
P M Lutterbeck
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
H Myron KauffmanYulin Cheng
© 2022 Meta ULC. All rights reserved