PMID: 16502480Feb 28, 2006Paper

Human papillomavirus type 16 E5 protein as a therapeutic target

Yonsei Medical Journal
Sang-Woo Kim, Joo-Sung Yang

Abstract

Cervical cancer is a progressive disease with an onset of one to two decades on average. During the productive replication stage, the Human papillomavirus (HPV) genome is maintained episomally in the infected cervical epithelium and early gene products, including E5, are expressed. Therefore, E5 has a potential to contribute to the HPV-associated carcinogenic process. In invasive malignancies, the HPV genomes are commonly integrated into the host genome, and E6 and E7 genes remain intact. However, the E5 is lost or, if present, under-expressed as compared with the E6 and E7 proteins. This suggests that E5 may play a critical role in the genesis of cervical cancer but less of a role in its persistence or progression. In the initiation of neoplasia and the premalignant stage, there are fewer malignant cells than in the invasive malignancies. Moreover, cells in the invasive malignant stage are found to have a very low level of MHC class I and II, which could hamper the presentation of the antigen and lead to a decreased immune response. Since the E5 protein is likely to play a role during the early tumorigenesis stage, a therapeutic vaccine to target and eliminate the E5-expressing cells may be a good strategy to prevent premalign...Continue Reading

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Sep 3, 2010·International Journal of Colorectal Disease·Laura LorenzonDeborah French
Jul 27, 2006·Southern Medical Journal·Salih KukMustafa Kaplan
Dec 6, 2007·BMC Biochemistry·Julia Shackelford, Joseph S Pagano
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