Human papillomavirus vaccine and cervical cancer prevention: practice and policy implications for pharmacists

Journal of the American Pharmacists Association : JAPhA
Jennifer McIntoshNiharika Khanna

Abstract

To review the epidemiology and natural history of human papillomavirus (HPV), summarize relevant clinical trials of the prophylactic HPV vaccines, and describe the practice and policy implications that HPV vaccine represents for pharmacists. Search of Medline through June 2007 using keywords human papillomavirus vaccine, Gardasil, and Cervarix; meeting abstracts; bibliographies from selected articles; and National Institutes of Health clinical trials registry. English language review articles, clinical trials, and published abstracts were considered for inclusion. HPV is a sexually transmitted infection that is necessary for the development of cervical cancer, and types 16 and 18 are associated with 70% of cases of invasive cervical cancer worldwide. A quadrivalent prophylactic vaccine against HPV-6, -11, -16, and -18 is currently available, and a bivalent vaccine targeting HPV-16 and -18 is under review by the Food and Drug Administration. Both are highly effective at preventing persistent HPV infection and precancerous lesions caused by vaccine-specific HPV. HPV vaccine is currently indicated for girls aged 9 to 26 years, but ongoing trials are evaluating the efficacy in other populations. Implementation of a vaccine administ...Continue Reading

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Citations

Dec 24, 2013·Gynecologic Oncology·Noel T BrewerJennifer S Smith
Mar 26, 2010·Journal of Community Health·Emily L McCave
Jun 24, 2010·Journal of Medical Virology·Chin-Hung WangChung-Yung Chen
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Jun 15, 2020·The Journal of Animal Ecology·Abhishek MishraSutirth Dey
Sep 8, 2019·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Alexis M KoskanDeborah L Helitzer
Jan 11, 2014·Expert Review of Vaccines·Parth D ShahNoel T Brewer

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