Human papillomaviruses and associated malignancies

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
R M Alani, K Münger

Abstract

The human papillomaviruses (HPVS) are small DNA tumor viruses that infect epithelial cells and induce proliferative lesions. Substantial epidemiologic data along with in vitro and in vivo studies have led to the implication of particular HPVs with the development of epithelial malignancies. Greater than 90% of all cervical carcinomas are positive for HPV infection. Most of these lesions are caused by infection with mucosal-associated high-risk HPV subtypes. Much work has been undertaken in basic science laboratories to determine the molecular basis for HPV-associated malignancies. Although many significant advances have been made in understanding the biologic properties of these viruses using in vitro analyses, the field has been greatly hindered until recently by the inability to propagate the virus in culture. In this review, we discuss the basic biologic properties of HPVs and the current understanding of the mechanisms of cellular transformation by malignancy-associated viral subtypes. We place particular emphasis on discussion of the HPV oncogenes, E6 and E7. We also discuss premalignant and malignant disorders of squamous and mucosal epithelia, which have been associated with HPV infections, and the current understanding ...Continue Reading

Citations

Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·W ZwerschkeP Jansen-Dürr
Jun 17, 1999·Clinical Obstetrics and Gynecology·T V Sedlacek
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C P Crum
Apr 12, 2000·Cancer Control : Journal of the Moffitt Cancer Center·C M CallahanR L Sandin
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S NauenburgP Jansen-Durr
Sep 25, 2001·Experimental Biology and Medicine·K N PrasadK C Prasad
Jul 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R SnoeckE De Clercq
Aug 10, 2002·Clinical Otolaryngology and Allied Sciences·M ShykhonK Pearman
Mar 31, 2009·International Journal of Cancer. Journal International Du Cancer·Anders NäsmanTina Dalianis
Oct 27, 2009·International Journal of Cancer. Journal International Du Cancer·Per AttnerEva Munck-Wikland
Aug 21, 2010·International Journal of Cancer. Journal International Du Cancer·Per AttnerEva Munck-Wikland
Aug 31, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Christos Kroupis, Nikolaos Vourlidis
Jul 28, 2006·Journal of Assisted Reproduction and Genetics·Andrew A HennebergPhilip J Chan
Feb 10, 2007·International Journal of Cancer. Journal International Du Cancer·Lindsey J GrayC Simon Herrington
Apr 7, 2007·The American Journal of Surgical Pathology·Sarah M BeanDavid C Chhieng
Apr 9, 2011·Apoptosis : an International Journal on Programmed Cell Death·Caiping GuoLaiqiang Huang
Jun 8, 2013·International Journal of Dermatology·Anna CampanatiAnna Offidani
Jan 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun HuJunfeng Xu
Mar 31, 2015·Bone Marrow Transplantation·Y InamotoN S Majhail
Jan 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul M WeinbergerAmanda Psyrri
Sep 12, 2000·Current Gastroenterology Reports·R W Goodgame
Apr 25, 2000·Indian Journal of Pediatrics·H P Wagner
Dec 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Sudip SenNeeta Singh
Feb 22, 2003·Current Treatment Options in Oncology·Samir N Khleif
Dec 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thanh U BarbiePatricia K Donahoe
Mar 12, 2009·Journal of the National Cancer Institute·Theodore RampiasAmanda Psyrri
Dec 22, 2012·Molecular Medicine Reports·Jun YangYing Pan
Nov 27, 2009·Diagnostic Cytopathology·Nalini GuptaArvind Rajwanshi
Dec 3, 2015·Journal of Medical Virology·Xuetao GuoShibo Jiang
Oct 10, 2013·International Journal of Cancer. Journal International Du Cancer·Guang-Dong LiaoYou-Lin Qiao
Mar 29, 2000·The Journal of Biological Chemistry·W ZwerschkeP Jansen-Dürr
Mar 10, 2001·Advances in Anatomic Pathology·J T KeatingC P Crum
Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S Nicholas AgoffLaura A Koutsky
Dec 24, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Christopher P Crum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal de gynécologie, obstétrique et biologie de la reproduction
C MouginD Riethmuller
Frontiers in Bioscience : a Journal and Virtual Library
Elizabeth A Sisk, Erle S Robertson
© 2021 Meta ULC. All rights reserved