PMID: 15383603Sep 24, 2004Paper

Human parvovirus B19 transgenic mice become susceptible to polyarthritis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Naruhiko TakasawaTakeshi Sasaki

Abstract

Human parvovirus B19 (B19) often causes acute polyarthritis in adults. In this paper, we analyzed nucleotide sequences of the B19 genome of patients with rheumatoid arthritis (RA), and then introduced the nonstructural protein 1 (NS1) gene of B19 into C57BL/6 mice that had a genetic origin not susceptible to arthritis. The transgenic mice developed no lesions spontaneously, but were susceptible to type II collagen (CII)-induced arthritis. B19 NS1 was expressed in synovial cells on the articular lesions that were histologically characteristic of granulomatous synovitis and pannus formation in cartilage and bone. Serum levels of anti-CII Abs and TNF-alpha increased in NS1 transgenic mice to the same levels as those of DBA/1 mice, which were susceptible to polyarthritis. Stimulation with CII increased secretion of Th1-type- and Th2-type cytokines in NS1 transgenic mice, indicating that a nonpermissive H-2(b) haplotype in the wild type of C57BL/6 mice can be made susceptible to polyarthritis through the expression of NS1. This study is the first to show that a viral agent from the joints in humans can cause CII-induced arthritis resembling RA.

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Citations

Nov 1, 2006·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Yasuhiko Munakata
Jan 9, 2007·Clinical Rheumatology·Taha Rashid, Alan Ebringer
Jul 3, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Danny Zipris
Jul 14, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Kouki Mori, Katsumi Yoshida
Dec 9, 2015·Journal of Clinical Pathology·Jonathan R Kerr
Sep 29, 2017·Current Diabetes Reports·James C Needell, Danny Zipris
May 16, 2019·Journal of Biochemistry·Kyoung-Woon KimSang-Heon Lee
Apr 5, 2008·Nature Protocols·Julia J InglisRichard O Williams
May 12, 2011·Expert Opinion on Therapeutic Targets·Chinnadurai Saravanan, Sushil Kumar Singh
Feb 22, 2011·Autoimmunity·Kouki MoriSadayoshi Ito
Jun 2, 2009·Rheumatic Diseases Clinics of North America·Ines Colmegna, Noah Alberts-Grill

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