Human-Pathogenic Kasokero Virus in Field-Collected Ticks.

Emerging Infectious Diseases
Amy J SchuhJonathan S Towner

Abstract

Kasokero virus (KASV; genus Orthonairovirus) was first isolated in 1977 at Uganda Virus Research Institute from serum collected from Rousettus aegyptiacus bats captured at Kasokero Cave, Uganda. During virus characterization studies at the institute, 4 laboratory-associated infections resulted in mild to severe disease. Although orthonairoviruses are typically associated with vertebrate and tick hosts, a tick vector of KASV never has been reported. We tested 786 Ornithodoros (Reticulinasus) faini tick pools (3,930 ticks) for KASV. The ticks were collected from a large R. aegyptiacus bat roosting site in western Uganda. We detected KASV RNA in 43 tick pools and recovered 2 infectious isolates, 1 of which was derived from host blood-depleted ticks. Our findings suggest that KASV is maintained in an enzootic transmission cycle involving O. (R.) faini ticks and R. aegyptiacus bats and has the potential for incidental virus spillover to humans.

References

Mar 1, 1986·The American Journal of Tropical Medicine and Hygiene·M KalundaJ Casals
Jan 1, 1985·Advances in Parasitology·H Hoogstraal
May 18, 1999·Preventive Veterinary Medicine·D W CowlingW O Johnson
Jun 27, 2006·Vector Borne and Zoonotic Diseases·Scott M ShoneNelson Delgado
Feb 9, 2008·Emerging Infectious Diseases·Robert SwanepoelUNKNOWN International Scientific and Technical Committee for Marburg Hemorrhagic Fever Control in the Democratic Republic of Congo
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lark L CoffeyScott C Weaver
Aug 4, 2009·PLoS Pathogens·Jonathan S TownerPierre E Rollin
Jan 7, 2010·BMC Bioinformatics·Ben C Stöver, Kai F Müller
Nov 23, 2013·Current Biology : CB·Mark S Springer
Jan 23, 2014·Emerging Infectious Diseases·César G AlbariñoUte Ströher
Jan 7, 2017·Virus Evolution·Nathan D GrubaughDoug E Brackney
May 5, 2017·Molecular Biology and Evolution·Vincent LefortOlivier Gascuel
Nov 14, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yongjin QiuHiroki Kawabata
Jan 22, 2019·Archives of Virology·Piet MaesJens H Kuhn
Dec 29, 2019·Parasites & Vectors·Attila D SándorSándor Hornok

❮ Previous
Next ❯

Citations

Mar 12, 2021·Frontiers in Microbiology·Amy H FitzpatrickPaul Cotter

❮ Previous
Next ❯

Methods Mentioned

BETA
reverse transcription PCR

Software Mentioned

Primal Scheme
PhyML
Geneious mapper
TreeGraph
HyPhy
BBDuk
Geneious

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.