Human Pavlovian fear conditioning conforms to probabilistic learning

PLoS Computational Biology
Athina TzovaraDominik R Bach

Abstract

Learning to predict threat from environmental cues is a fundamental skill in changing environments. This aversive learning process is exemplified by Pavlovian threat conditioning. Despite a plethora of studies on the neural mechanisms supporting the formation of associations between neutral and aversive events, our computational understanding of this process is fragmented. Importantly, different computational models give rise to different and partly opposing predictions for the trial-by-trial dynamics of learning, for example expressed in the activity of the autonomic nervous system (ANS). Here, we investigate human ANS responses to conditioned stimuli during Pavlovian fear conditioning. To obtain precise, trial-by-trial, single-subject estimates of ANS responses, we build on a statistical framework for psychophysiological modelling. We then consider previously proposed non-probabilistic models, a simple probabilistic model, and non-learning models, as well as different observation functions to link learning models with ANS activity. Across three experiments, and both for skin conductance (SCR) and pupil size responses (PSR), a probabilistic learning model best explains ANS responses. Notably, SCR and PSR reflect different quan...Continue Reading

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Citations

Aug 20, 2019·Psychophysiology·Charlotte PietrockFlorian Schlagenhauf
Jan 7, 2020·PLoS Computational Biology·Filip Melinscak, Dominik R Bach
Oct 11, 2019·PLoS Computational Biology·Toby WiseRaymond J Dolan
Jul 2, 2020·Social Cognitive and Affective Neuroscience·Lei ZhangClaus Lamm
Aug 18, 2020·Translational Psychiatry·Josh M CislerClinton D Kilts
Nov 11, 2020·Behavior Research Methods·Yanfang XiaDominik R Bach
Jan 2, 2021·Trends in Cognitive Sciences·Ifat Levy, Daniela Schiller
Nov 23, 2020·NeuroImage·Matthias F J SperlErik M Mueller
May 24, 2021·Neuroscience and Biobehavioral Reviews·Patrick A F Laing, Ben J Harrison
May 22, 2021·Behaviour Research and Therapy·Kevin M CrombieJosh M Cisler
Jul 10, 2021·Behavior Research Methods·Tricia X F Seow, Tobias U Hauser
Aug 26, 2021·Molecular Psychiatry·Jonathan W KanenTrevor W Robbins
Oct 9, 2021·Scientific Reports·Harry J Stewardson, Thomas D Sambrook
Nov 28, 2021·Psychophysiology·Lauren Y AtlasElizabeth A Phelps

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Software Mentioned

Matlab fmincon
R
PsPM
EyeLink 1000
nlme
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