PMID: 2499534Jan 1, 1989Paper

Human Peyer's patches: lympho-epithelial relationships and characteristics of immunoglobulin-producing cells

Immunological Investigations
P Brandtzaeg, K Bjerke

Abstract

Human Peyers patches (PP) were studied by immunohistochemistry to characterize functional properties of the follicle-associated epithelium (FAE) including the "membrane" (M) cells. The FAE had no transporting capacity for polymeric IgA (pIgA) because it did not express the secretory component (SC) which acts as a pIgA receptor. However, it expressed MHC class II (HLA-DR) determinants, except for the M cells (which were tentatively identified by absence of brush border alkaline phosphatase). It is possible, therefore, that the FAE generally performs class II-restricted transport and presentation to T cells of antigens which have been adequately processed in the gut lumen. The function of M cells may be limited to transport of particulate or undegraded antigens to subjacent macrophages for processing and subsequent presentation. There were significantly more intra- and subepithelial T cells in PP than in distant villi, and the T cells were concentrated adjacent to M cells. The proportion of the CD4+ phenotype (putative helper T cells) was much higher in FAE (approximately 40%) than in villous epithelium where the CD8+ (putative suppressor) phenotype predominated strikingly (approximately 90%). This disparity might reflect differe...Continue Reading

References

Aug 1, 1988·Gut·P BrandtzaegT O Rognum
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·P Brandtzaeg
Jun 30, 1983·Annals of the New York Academy of Sciences·J M Phillips-QuagliataM E Lamm
Jan 1, 1984·European Journal of Immunology·J D Reynolds, B Morris
Jan 1, 1987·Immunology Today·P M Allen

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Citations

Jan 1, 1997·Springer Seminars in Immunopathology·I C Davis, R L Owen
Jul 1, 1997·The Anatomical Record·A KrackeR Pabst
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas J MantisMarian R Neutra
Jan 14, 2000·Journal of Pediatric Gastroenterology and Nutrition·L Mayer
Jan 1, 1994·Critical Reviews in Microbiology·Y u PolotskyT h Khavkin
Aug 23, 2002·Immunological Reviews·Rolf M Zinkernagel
Sep 1, 1996·Immunological Investigations·R M CarrN L O'Sullivan
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter VelázquezJonathan Braun
Dec 23, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·L K GordonJ Braun
Jul 19, 2002·Gastroenterology Clinics of North America·Scott Plevy

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