PMID: 598411Dec 16, 1977

Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules

European Journal of Clinical Pharmacology
L M FuccellaG Tognoni

Abstract

Plasma levels of temazepam were determined in healthy subjects after single oral administration of soft and hard gelatin capsules, and after 7 consecutive night-time doses in soft capsules. Absorption from soft gelatin capsules was significantly faster and produced earlier and higher peak plasma levels. The two pharmaceutical forms did not show any significant difference in relative availability. The apparent half-life of temazepam after night-time administration was significantly shorter than after morning administration, but no change in half-life was observed between the first and seventh night-time doses.

References

Jun 1, 1976·British Journal of Clinical Pharmacology·A N NicholsonH M Ferres
Jun 1, 1975·British Journal of Clinical Pharmacology·G TognoniG Scieghi
Jun 15, 1976·European Journal of Clinical Pharmacology·U KlotzP R Bieck
Jan 1, 1974·Psychopharmacologia·M TansellaM Lader
Aug 23, 1974·European Journal of Clinical Pharmacology·M LinnoilaM Maki
Dec 1, 1973·Journal of Pharmaceutical Sciences·S A KaplanL Weissman
Aug 1, 1976·British Journal of Clinical Pharmacology·A N Nicholson, B M Stone

Citations

Jun 1, 1988·European Journal of Pediatrics·C O'CallaghanA Swarbrick
Jan 1, 1981·European Journal of Clinical Pharmacology·W Lehmann, B Liljenberg
Jan 1, 1986·European Journal of Clinical Pharmacology·K KlemK Laake
Jan 1, 1986·European Journal of Clinical Pharmacology·H GhabrialM L Mashford
Apr 9, 1988·Lancet·A P Launchbury
May 14, 1988·Lancet
Jan 1, 1979·British Journal of Clinical Pharmacology·D D Breimer
Jan 1, 1979·British Journal of Clinical Pharmacology·L M Fuccella
Jan 1, 1979·British Journal of Clinical Pharmacology·P BittencourtA N Latham
Jan 1, 1990·British Journal of Clinical Pharmacology·G A FordT F Blaschke
Feb 1, 1992·British Journal of Clinical Pharmacology·T H LebedevsK F Ilett
Jun 1, 1992·British Journal of Clinical Pharmacology·J P FeeR S Clarke
Oct 1, 1991·Journal of Clinical Pharmacy and Therapeutics·J DrakeC Whateley-Smith
Mar 1, 1980·British Medical Journal·R S BriggsC A Kraft
Jan 28, 1995·BMJ : British Medical Journal·N A BuckleyD L O'Connell
Jan 1, 1987·European Journal of Clinical Pharmacology·F O MüllerG C Dunbar
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·H G Schroeder
Jan 1, 1983·Journal of Chronic Diseases·J Crooks
Aug 1, 1989·Anaesthesia·J IrjalaM Salonen
Dec 1, 1987·British Journal of Clinical Pharmacology·J M PatrickP H Fentem
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·I Hindmarch
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·J F O'Hanlon, E R Volkerts
Aug 1, 1980·Anaesthesia·K Amarasekera
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·J Kanto
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·L Dettli
Apr 1, 1982·Anaesthesia·G ClarkE Major
Jan 1, 1981·Anaesthesia·A P BeecheyC Studd
Mar 1, 1980·British Journal of Clinical Pharmacology·A N Nicholson
Jun 1, 1980·British Journal of Clinical Pharmacology·T V Harry, A N Latham
Nov 1, 1986·Acta Anaesthesiologica Scandinavica·M SalonenO Viinamäki
Jan 1, 1984·Journal of Clinical Pharmacology·H R OchsH Heuer
Apr 1, 1988·Journal of Clinical Pharmacology·S R BareggiS Smirne
Jan 1, 1978·The Journal of International Medical Research·R S Middleton
Jan 1, 1979·The Journal of International Medical Research·H S Sussman
May 1, 1979·Acta Pharmacologica Et Toxicologica·R Liljequist, M J Mattila
Jul 1, 1981·Pharmacotherapy·M M Mitler
Oct 1, 1985·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P N Trennery, R H Waring
Sep 1, 1982·Drug Intelligence & Clinical Pharmacy·J C McElnayB Alexander
Jan 1, 1981·British Journal of Clinical Pharmacology·A N Nicholson
Apr 1, 1983·The Journal of Pharmacy and Pharmacology·F L TseH J Schwarz
Aug 1, 1987·British Journal of Clinical Pharmacology·R B CharlesS P Parker
Jan 1, 1981·British Journal of Clinical Pharmacology·D J GreenblattJ S Harmatz
Oct 1, 1982·Postgraduate Medicine·J Ananth
May 1, 1989·Anaesthesia and Intensive Care·T G Short, D C Galletly
Jan 1, 1986·Acta Pharmacologica Et Toxicologica·M SalonenJ Kanto

Related Concepts

Biological Availability
Microcapsules Drug Delivery System
Valium
Half-Life

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.