Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine

Science China. Life Sciences
Sufang HanJianwu Dai

Abstract

Traumatic spinal cord injury (SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold (LOCS) and human placenta-derived mesenchymal stem cells (hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment (control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans (CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin (Tuj-1)- and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending (CGRP-positive) sensory fibers and descending (5-HT- and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in...Continue Reading

References

Oct 11, 2001·American Journal of Veterinary Research·N J OlbyB W Keene
Feb 2, 2002·Experimental Hematology·Amelia BartholomewRonald Hoffman
Jun 22, 2002·Nature·Yuehua JiangCatherine M Verfaillie
Sep 3, 2004·Stem Cells·Yumi FukuchiKohichiro Tsuji
Dec 31, 2004·Stem Cells·B Linju YenYao-Chang Chen
Jan 28, 2005·Journal of Neurotrauma·Kim D Anderson
Jul 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qilin CaoScott R Whittemore
Jul 22, 2006·Nature Reviews. Neuroscience·Sandrine ThuretFred H Gage
Jul 22, 2006·Nature Reviews. Neuroscience·Elizabeth J Bradbury, Stephen B McMahon
Mar 23, 2007·Journal of Neurotrauma·Venkata Ramesh DasariDzung H Dinh
Jun 20, 2008·Reviews in the Neurosciences·Aysha Z AkhtarChad B Sandusky
Aug 25, 2009·Journal of Neurotrauma·Karin S StraleySarah C Heilshorn
Sep 22, 2009·Nature Neuroscience·Grégoire CourtineV Reggie Edgerton
Feb 23, 2011·Tissue Engineering. Part B, Reviews·Mindan WangFuzhai Cui
Apr 29, 2011·Journal of Visualized Experiments : JoVE·Christopher K ThompsonT George Hornby
Sep 10, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Edmund R Hollis, Mark H Tuszynski
Dec 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicholas D JamesElizabeth J Bradbury
Jun 12, 2012·Neuron·Mark H Tuszynski, Oswald Steward
Oct 17, 2012·Neurochemistry International·Wen-Jie LiYuan-Shan Zeng
Jul 9, 2013·Experimental Neurology·Lars Olson
Feb 13, 2014·Experimental and Therapeutic Medicine·Wenchen JiYuelin Zhang
Aug 27, 2014·Stem Cell Research & Therapy·Bikesh ShresthaLi Yao
May 20, 2015·Science China. Life Sciences·Liang DongXiaoBing Fu
Jul 1, 2015·Stem Cells International·Rita C Assunção-SilvaAntónio J Salgado
Aug 13, 2015·BMC Medicine·Naomi D'souzaMassimo Dominici
Jan 28, 2016·Regenerative Biomaterials·Liliana R Pires, Ana P Pêgo

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Citations

Nov 30, 2018·Stem Cells and Development·Jiayi WangJing Liu
Mar 18, 2020·Current Stem Cell Research & Therapy·Masoumeh AlishahiSeyed E Khoshnam
Jul 4, 2018·BioMed Research International·Shuangshuang WangXiaomin Chen
Apr 10, 2019·Neural Regeneration Research·Shuo LiuBin Wang
Jul 24, 2020·International Journal of Molecular Sciences·Zuzana VikartovskaDasa Cizkova
Dec 4, 2020·Tissue Engineering. Part B, Reviews·Jiao Jiao LiBin Zhao
Feb 3, 2019·Acta Biomaterialia·Qingzheng ZhangXuesi Chen
Nov 17, 2020·Frontiers in Veterinary Science·Melissa J LewisUNKNOWN Canine Spinal Cord Injury Consortium (CANSORT-SCI)
Apr 9, 2021·International Journal of Pharmaceutics·Amina T Mneimneh, Mohammed M Mehanna

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