Abstract
Intracerebral hemorrhage (ICH) is a critical disease, highly associated with mortality and morbidity. Several studies have demonstrated the beneficial effect of mesenchymal stem cells (MSCs) on ICH, mostly focused on their mid-to-long-term effect. Acute hematoma expansion is one of the most important prognostic factors of ICH. We hypothesized that MSCs would decrease mortality and hematoma size in acute ICH, based on the findings of a few recent researches reporting their effect on blood-brain barrier and endothelial integrity. Rat ICH models were made using bacterial collagenase. One hour after ICH induction, the rats were randomly divided into MSC-treated and control groups. Mortality, hematoma volume, ventricular enlargement, brain edema, and degenerating neuron count were compared at 24 hours after ICH induction. Expression of tight junction proteins (ZO-1, occludin) and coagulation factor VII mRNA was also compared. Mortality rate (50% versus 8.3%), hematoma size, ventricular size, hemispheric enlargement, and degenerating neuron count were significantly lower in the MSC-treated group (p = 0.034, 0.038, 0.001, 0.022, and <0.001, resp.), while the expression of ZO-1 and occludin was higher (p = 0.007 and 0.012). Administrat...Continue Reading
References
Mar 1, 1978·Stroke; a Journal of Cerebral Circulation·S SantambrogioA Randazzo
Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·Y L YuK Y Fong
May 14, 1987·The New England Journal of Medicine·N PoungvarinB L Strom
Dec 1, 1996·Stroke; a Journal of Cerebral Circulation·M R Del BigioJ Peeling
Jun 17, 1998·Stroke; a Journal of Cerebral Circulation·Y FujiiR Tanaka
Feb 2, 2000·Nature Medicine·G T ManleyA S Verkman
Aug 29, 2000·Brain Research·L C Schmued, K J Hopkins
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Stephan A Mayer
Feb 25, 2005·The New England Journal of Medicine·Stephan A MayerUNKNOWN Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators
Apr 26, 2006·Neurology·S M DavisUNKNOWN Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Ya HuaGuohua Xi
Aug 19, 2007·Behavior Research Methods·Franz FaulAxel Buchner
Oct 17, 2007·Circulation·Joseph BroderickUNKNOWN Quality of Care and Outcomes in Research Interdisciplinary Working Group
Dec 7, 2007·Neurocritical Care·Michael Lucas JamesDaniel T Laskowitz
May 16, 2008·The New England Journal of Medicine·Stephan A MayerUNKNOWN FAST Trial Investigators
Aug 5, 2008·Neuroscience·J Wang, S Doré
Mar 17, 2009·Stroke; a Journal of Cerebral Circulation·Masanobu OkauchiGuohua Xi
May 12, 2009·Lancet·Adnan I QureshiDaniel F Hanley
Aug 28, 2009·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wenbin LiaoZhong Chao Han
Sep 5, 2009·Stroke; a Journal of Cerebral Circulation·Elisabet ZiaHélène Pessah-Rasmussen
Jan 7, 2011·Cytotherapy·Laura OteroJesus Vaquero
Feb 12, 2011·Neurosurgery·Chaoxian YangQionglan Yuan
Nov 1, 2011·Journal of Neuroinflammation·Edwin B YanM Cristina Morganti-Kossmann
Dec 17, 2011·Lancet Neurology·Joyce S Balami, Alastair M Buchan
Jun 30, 2012·Neurology·Candice DelcourtUNKNOWN INTERACT1 Investigators
Jul 10, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Masoumeh SeghatoleslamAlireza Fazel
Jul 25, 2012·Molecular Medicine Reports·Su-Ping WangXiao-Hong Wang
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Oct 9, 2012·Journal of Cellular Physiology·Chad SanadaGraça Almeida-Porada
Dec 22, 2012·Acta Haematologica·Moon Ju JangHyung-Min Chung
May 17, 2014·PloS One·Wei ZhuJian Wang
Sep 12, 2014·Anesthesiology·Antoine MonselJae W Lee
Dec 31, 2014·Stem Cells Translational Medicine·Tae Nyoung ChungSang Won Suh
Apr 19, 2015·Journal of Neuroinflammation·Min ChenChuanzhi Duan
Apr 29, 2015·World Journal of Stem Cells·Marcos F Cordeiro, Ana P Horn
May 15, 2015·Stem Cells·Birgitta M GleesonNoel M Caplice
May 30, 2015·Stroke; a Journal of Cerebral Circulation·J Claude HemphillUNKNOWN Council on Clinical Cardiology
Sep 28, 2015·Molecular Neurobiology·Yang HuZhouping Tang
Mar 3, 2017·Critical Care Medicine·Tae Nyoung ChungSang Won Suh
Jun 20, 2017·The Journal of Trauma and Acute Care Surgery·Barbara A ChristyAndrew P Cap
Citations
May 18, 2020·Molecular Biology Reports·Abel Po-Hao HuangDar-Ming Lai
May 28, 2020·International Journal of Molecular Sciences·Min Kyoung KangByung-Woo Yoon
Mar 13, 2020·Stem Cells and Development·Tanira Giara MelloPedro Moreno Pimentel-Coelho
Nov 25, 2018·International Journal of Molecular Sciences·Saehong MinTae Nyoung Chung
Dec 22, 2020·EBioMedicine·Mansoureh BarzegarJonathan S Alexander
Mar 5, 2021·Stem Cell Reviews and Reports·Li DengChaoxian Yang
Apr 13, 2021·Frontiers in Cellular Neuroscience·Yu-Hua GongBo-Chu Wang
May 1, 2021·Frontiers in Aging Neuroscience·Jing LiHaitao Sun
May 1, 2021·Reproductive Biology·Prasad Pethe, Vaijayanti Kale