Human Placental Extract as a Subcutaneous Injection Is Effective in Chronic Fatigue Syndrome: A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study

Biological & Pharmaceutical Bulletin
Sat Byul ParkHo Cheol Shin

Abstract

Chronic fatigue (CF) is a common reason for consulting a physician due to affecting quality of life, but only a few effective treatments are available. The aim of this study was to examine the effectiveness of subcutaneous injection of the human placental extract (HPE) on medically indescribable cases of CF and safety in a randomized, double-blind, placebo-controlled clinical trial. A total of 78 subjects with CF were randomly assigned to either a HPE group or a placebo group. Subjects in the HPE group were treated with HPE three times a week subcutaneously for 6 weeks, whereas those in the placebo group with normal saline. Then, the fatigue severity scale (FSS), visual analog scale (VAS) and multidimensional fatigue inventory (MFI) were measured in both CF group and chronic fatigue syndrome (CFS) and idiopathic chronic fatigue (ICF) subgroup. The FSS, VAS and MFI score at baseline were not different between the HPE and placebo group in total subjects with CF. In CFS group, the FSS (p=0.0242), VAS (p=0.0009) and MFI (p=0.0159) scores measured at the end of the study period decreased more in the HPE group than in the placebo group when compared with those at the baseline. There were no significant differences between the HPE gro...Continue Reading

References

Apr 1, 1995·Journal of Psychosomatic Research·E M SmetsJ C De Haes
Dec 1, 1996·Current Opinion in Neurology·L B Krupp, D A Pollina
Feb 24, 2001·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·L KleinmanD Revicki
Sep 19, 2001·JAMA : the Journal of the American Medical Association·P WhitingG Ramírez
Jul 26, 2002·The Cochrane Database of Systematic Reviews·H V WorthingtonO B Eden
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael B AtkinsDavid McDermott
Feb 22, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Piyali Datta Chakraborty, Debasish Bhattacharyya
Sep 19, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·L D Devanur, J R Kerr
Dec 20, 2007·Menopause : the Journal of the North American Menopause Society·Mi-Hee KongSat-Byul Park
Oct 4, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Kang-Kon LeeMoon-Jong Kim
Oct 11, 2011·BMC Complementary and Alternative Medicine·Terje AlraekJianping Liu

❮ Previous
Next ❯

Citations

Aug 23, 2018·Journal of Cellular Physiology·Dong-Ho BakBeom Joon Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Dan A MendonçaMandar S Jog
The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
Jae-Hyung LeeJae-Woo Park
Phytotherapy Research : PTR
Farzaneh Agha-HosseiniAida Karagah
© 2022 Meta ULC. All rights reserved