PMID: 11904616Mar 21, 2002Paper

Human placental growth hormone causes severe insulin resistance in transgenic mice

American Journal of Obstetrics and Gynecology
Linda A BarbourJacob E Friedman

Abstract

The insulin resistance of pregnancy is considered to be mediated by human placental lactogen, but the metabolic effects of human placental growth hormone have not been well defined. Our aim was to evaluate the effect of placental growth hormone on insulin sensitivity in vivo using transgenic mice that overexpress the human placental growth hormone gene. Glucose and insulin tolerance tests were performed on 5 transgenic mice that overexpressed the human placental growth hormone variant gene and 6 normal littermate controls. The body composition of the mice was assessed by dual-energy radiograph absorptiometry, and free fatty acid levels were measured as a marker of lipolysis. The human placental growth hormone levels in the transgenic mice were comparable to those attained in the third trimester of pregnancy. These mice were nearly twice as heavy as the control mice, and their body composition differed by a significant increase in bone density and a small decrease in percentage of body fat. Fasting insulin levels in the transgenic mice that overexpressed placental growth hormone were approximately 4-fold higher than the control mice (1.57 +/- 0.22 ng/mL vs 0.38 +/- 0.07 ng/mL; P <.001) and 7 times higher 30 minutes after glucose...Continue Reading

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Citations

Mar 29, 2008·Metabolic Syndrome and Related Disorders·James F Clapp
May 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Virginia L BrooksCheryl M Heesch
Jul 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margaret J R HeerwagenJacob E Friedman
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