Human placental growth hormone

American Journal of Obstetrics and Gynecology
E AlsatD Evain-Brion

Abstract

Placental growth hormone is the product of the GH-V gene specifically expressed in the syncytiotrophoblast layer of the human placenta. Placental growth hormone differs from pituitary growth hormone by 13 amino acids. It has high somatogenic and low lactogenic activities. Assays by specific monoclonal antibodies reveal that in the maternal circulation from 15 to 20 weeks up to term placental growth hormone gradually replaces pituitary growth hormone, which becomes undetectable. It is secreted by the placenta in a nonpulsatile manner. This continuous secretion appears to have important implications for physiologic adjustment to gestation and especially in the control of maternal insulin-like growth factor-I levels. Placental growth hormone secretion is inhibited by glucose in vitro and in vivo and is significantly decreased in the maternal circulation in pregnancies with intrauterine growth restriction. Placental growth hormone does not appear to have a direct effect on fetal growth because this hormone is not detectable in the fetal circulation. However, the physiologic role might also include a direct influence on placental development through an autocrine or paracrine mechanism, as suggested by the presence of specific growth...Continue Reading

References

Jan 31, 1992·Biochemical and Biophysical Research Communications·F FrankenneD Evain-Brion
Oct 30, 1992·Cell·S Strickland, W G Richards
Aug 1, 1991·The Journal of Clinical Endocrinology and Metabolism·E AlsatD Evain-Brion
Aug 1, 1991·Endocrine Reviews·P A KellyM Edery
Dec 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G BaumannN E Cooke
Sep 1, 1990·The Journal of Clinical Endocrinology and Metabolism·A BeckersF Frankenne
Aug 1, 1990·The Journal of Clinical Endocrinology and Metabolism·F de ZegherF Frankenne
Jul 1, 1990·The Journal of Clinical Endocrinology and Metabolism·F FrankenneG Hennen
Jan 1, 1990·Hormone Research·D Evain-BrionF Frankenne
Mar 1, 1988·Archives internationales de physiologie et de biochimie·A IgoutG Hennen
Nov 1, 1989·The Journal of Clinical Endocrinology and Metabolism·C S JaraF Frankenne
Jun 1, 1989·The Journal of Clinical Investigation·S A LiebhaberN E Cooke
Jul 1, 1989·Endocrinology·J RayN E Cooke
Aug 1, 1989·British Journal of Obstetrics and Gynaecology·L ErikssonB Von Schoultz
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R F SeldenH M Goodman
Jan 1, 1988·Acta Obstetricia Et Gynecologica Scandinavica·L ErikssonB von Schoultz
Jun 1, 1988·The Journal of Clinical Endocrinology and Metabolism·F FrankenneG Hennen
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·F FrankenneG Hennen
Aug 1, 1973·The Journal of Clinical Endocrinology and Metabolism·T Tsushima, H G Friesen
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·H D NiallF C Greenwood
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G N PavlakisD H Hamer
Jan 1, 1981·Annual Review of Physiology·E R Simpson, P C MacDonald
Aug 11, 1981·Nucleic Acids Research·F M DeNotoH M Goodman
Jun 25, 1983·Nucleic Acids Research·G S BarshR E Gelinas
Jan 1, 1983·Endocrine Reviews·W L Miller, N L Eberhardt
May 15, 1981·Science·D OwerbachT B Shows
Jan 1, 1995·Vitamins and Hormones·N E Cooke, S A Liebhaber
May 1, 1995·The Journal of Clinical Endocrinology and Metabolism·N PatelD Evain-Brion

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Citations

Feb 19, 2014·Placenta·E MenkhorstE Dimitriadis
Sep 24, 2010·International Journal of Endocrinology·Syed Ali ImranShereen Ezzat
Jul 20, 2007·Molecular and Cellular Biology·Atsushi P KimuraStephen A Liebhaber
Jun 5, 2012·Reproductive Toxicology·Asher Ornoy
Sep 24, 2011·Physiology & Behavior·Michael L Power, Jay Schulkin
Feb 1, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Alessia SagazioRoberto Salvatori
Dec 18, 2009·Trends in Endocrinology and Metabolism : TEM·Sebastian Rieck, Klaus H Kaestner
Jul 3, 2008·American Journal of Reproductive Immunology : AJRI·Ann-Christin StenqvistLucia Mincheva-Nilsson
May 11, 2006·Drug Metabolism Reviews·Agneta Mode, Jan-Ake Gustafsson
Apr 30, 2002·Placenta·M C LacroixD Evain-Brion
Apr 16, 2013·American Journal of Obstetrics and Gynecology·Alicia MandujanoPatrick M Catalano
Apr 2, 1999·Acta Paediatrica. Supplement·D Evain-Brion
Dec 7, 2000·Clinical Endocrinology·J VerhaegheA Igout
Nov 5, 2016·Biologie aujourd'hui·Pascale GerbaudGuillaume Pidoux
Mar 16, 2017·European Journal of Endocrinology·Julio AbuchamMonike L Dias
Mar 16, 2011·Nature Reviews. Endocrinology·Marcello D BronsteinRaquel S Jallad
Oct 20, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Trond M MichelsenThomas Jansson
Jun 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Jefferson P LomenickStuart Handwerger
May 15, 2010·Expert Review of Molecular Diagnostics·M P H Wendy KosterPeter C J I Schielen
Oct 12, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Dorothee Newbern, Michael Freemark
Aug 19, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Pooja MittalRoberto Romero
Apr 25, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·S Handwerger, M Freemark
Jan 28, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·B XuC-C Hsieh
Aug 15, 2017·Biomedical Reports·Alexandros VelegrakisStavros Sifakis
Sep 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·A TarradeD Evain-Brion
Aug 29, 1998·Molecular and Cellular Endocrinology·E AlsatD Evain-Brion
Aug 7, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M J Waters, P L Kaye
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Danièle Evain-Brion, André Malassine
Jan 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Torben Laursen
Oct 4, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P MittalR Romero

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