Human placental lactogen: studies of its acute metabolic effects and disposition in normal man

The Journal of Clinical Investigation
P Beck, W H Daughaday

Abstract

The acute metabolic effects and disposition of human placental lactogen (HPL) have been studied in 15 men and 8 women during continuous intravenous infusions. The mean plasma half-life, metabolic pool size, and turnover rate of HPL are comparable to the values previously reported for human growth hormone (HGH). From the data presented, we calculate that the placenta secretes approximately 290 mg HPL daily at term. After 12-hour infusions of HPL in physiologic amounts, impairment of glucose tolerance despite increased plasma insulin responses to glucose was observed in 7 of 8 subjects tested. However, HPL, unlike HGH, did not produce significant changes in blood glucose, plasma insulin, or plasma free fatty acid concentrations in fasting subjects before glucose administration or in carbohydrate tolerance or plasma insulin responses to glucose during 5-hour infusions. These findings are compatible with the thesis that HPL is a physiologic antagonist to insulin during pregnancy.

References

Jan 6, 1966·The New England Journal of Medicine·J Worcester
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·S L Kaplan, M M Grumbach
Apr 1, 1966·The Journal of Clinical Endocrinology and Metabolism·M M GrumbachF A Conte
Jul 1, 1966·Endocrinology·J R TurtleW H Daughaday
Feb 1, 1956·The Journal of Clinical Investigation·V P DOLE
Jan 1, 1961·The Journal of Clinical Investigation·J F TAITK R LAUMAS
Nov 1, 1960·The American Journal of Medicine·D B ZILVERSMIT
Feb 1, 1960·Acta Endocrinologica·P DE MOORA HENDRIKX
Dec 1, 1962·The Journal of Endocrinology·R FRASERD RABINOWITZ
May 2, 1963·The New England Journal of Medicine·W N SPELLACY, F C GOETZ
Nov 1, 1963·Clinica Chimica Acta; International Journal of Clinical Chemistry· VAN MOLENH
Nov 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·H COHENS L KAPLAN
Dec 1, 1964·Transactions of the New York Academy of Sciences·J B JOSIMOVICH, B L BRANDE
Feb 1, 1962·The Journal of Obstetrics and Gynaecology of the British Empire·E J ROY, R MACKAY

❮ Previous
Next ❯

Citations

Jul 1, 1980·Diabetologia·P M FisherP D Bewsher
Jul 1, 1980·Diabetologia·P M FisherP D Bewsher
Jul 1, 1973·Acta diabetologica latina·C López-Quijada, E Sintas
Jul 18, 2003·Current Diabetes Reports·Eyal Sivan, Guenther Boden
Jan 1, 1986·Physiology & Behavior·D K ThomasK Gillette
Apr 1, 1982·Molecular and Cellular Endocrinology·D WeinsteinA A Hochberg
Nov 21, 1968·The New England Journal of Medicine·J B StanburyY Ochi
Jul 31, 1969·The New England Journal of Medicine·B N SaxenaH A Selenkow
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Derek E WildmanRoberto Romero
Apr 14, 1973·British Medical Journal·W UrsellT Chard
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marcia R BatistaMary Courtney Moore
May 1, 1971·The Journal of Clinical Investigation·N V Costrini, R K Kalkhoff
Jul 12, 2014·Human Reproduction Update·Vanitha N SivalingamEmma J Crosbie
Jun 1, 1976·British Journal of Obstetrics and Gynaecology·T Lind, V G Harris
Feb 1, 1976·British Journal of Obstetrics and Gynaecology·M M Singh
Mar 1, 1974·The Journal of Obstetrics and Gynaecology of the British Commonwealth·U GaspardA Luyckx
Dec 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·T LindG Brown
Dec 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·B S Lindberg, B A Nilsson
Jul 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·A R GenazzaniP Fioretti
Mar 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·T S Spencer
Aug 1, 1970·The Journal of Obstetrics and Gynaecology of the British Commonwealth·P FiorettiA Pupillo
Jan 1, 1978·British Journal of Obstetrics and Gynaecology·C Williams, T M Coltart
Aug 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·D V Fairweather
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·C T Jones
Jul 4, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xuejun ShangguanMinyue Dong
Nov 1, 1987·Placenta·R L Ingermann
Jul 1, 1969·Metabolism: Clinical and Experimental·A R GenazzaniJ P Felber
Jun 1, 1984·Metabolism: Clinical and Experimental·M B Davidson
Dec 1, 1975·The Journal of Pediatrics·S HandwergerR E Fellows
Jul 1, 1984·Equine Veterinary Journal·A L FowdenM Silver
Nov 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·R S GrayL J Duncan
Mar 1, 1996·Obstetrics and Gynecology Clinics of North America·G Boden
Mar 4, 2015·American Journal of Obstetrics and Gynecology·Luciana LassanceSylvie Hauguel-de Mouzon
Dec 8, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Liat SalzerMoshe Hod
Apr 1, 1972·Clinical Endocrinology·M Hartog
Dec 1, 1995·History of Psychiatry·G E Berrios, J M Olivares

❮ Previous
Next ❯

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