Human placental monoamine transporters as targets for amphetamines

American Journal of Obstetrics and Gynecology
J D RamamoorthyV Ganapathy

Abstract

The use of amphetamine and its derivatives during pregnancy is known to have adverse effects on the outcome of pregnancy. These effects are at least partly a result of impairment of placental function caused by these abusable drugs. We hypothesized that the two monoamine transporters, namely, the serotonin transporter and the norepinephrine transporter, that are expressed in the human placenta are direct targets for these drugs. The interaction of amphetamine and methamphetamine with human placental serotonin and norepinephrine transporters was examined. Activity of the serotonin transporter was assessed by serotonin uptake in both maternal-facing brush border membrane vesicles isolated from normal term human placentas and in JAR choriocarcinoma cells. Activity of the norepinephrine transporter was assessed by dopamine uptake and nisoxetine binding in placental brush border membrane vesicles. Amphetamine and methamphetamine are potent inhibitors of the serotonin and norepinephrine transporters expressed in the human placenta. The inhibitory potency of amphetamine is greater than that of methamphetamine. In each case, the S(+)diastereoisomer is more potent than the corresponding R(-)diastereoisomer. The sensitivity of the norepi...Continue Reading

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Citations

Feb 8, 2007·Archives of Gynecology and Obstetrics·Vorapong Phupong, Darigar Darojn
Aug 24, 1999·American Journal of Obstetrics and Gynecology·S P KenneyV Ganapathy
Jun 6, 2000·Advanced Drug Delivery Reviews·V GanapathyF H Leibach
Jun 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·K L Audus
Apr 18, 2002·British Journal of Pharmacology·Lankupalle D JayanthiLouis J DeFelice
Jun 13, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sarah J WhiteSamuel Michael Owens
Dec 16, 2005·The AAPS Journal·Lankupalle D Jayanthi, Sammanda Ramamoorthy
Jun 2, 2004·Clinical Pharmacokinetics·Michael R SymeJeffrey A Keelan
Jun 2, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·J L OeiM E Abdel-Latif
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S A FuraraS W Lindow
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Sep 30, 2009·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Jan 13, 2016·Journal of Analytical Toxicology·Lucia BurraiGianpiero Boatto
Oct 12, 2010·Life Sciences·Vadivel Ganapathy
Sep 8, 2009·Clinics in Perinatology·Amy L SalisburyBarry M Lester
Jan 1, 2008·Environmental Toxicology and Pharmacology·Turgay Sişman, Fatime Geyikoğlu
Oct 1, 2009·British Journal of Pharmacology·Kirsi Vähäkangas, Päivi Myllynen
Aug 3, 2011·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Corinne DelsingRalph Nanan
Oct 11, 2015·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Chulathida ChomchaiRatchada Kitsommart
Jun 19, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emily J RossGregg D Stanwood
May 21, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sarah J WhiteS Michael Owens
Jul 8, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Caroline Prouillac, Sylvaine Lecoeur
Aug 19, 2004·The Journal of Pharmacology and Experimental Therapeutics·Erik Rytting, Kenneth L Audus
Sep 1, 2010·Obstetric Medicine·Katherine Scott, Karin Lust
Aug 1, 2012·Physiological Research·R Šlamberová

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