Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries

Prostaglandins
M F GimenoA L Gimeno

Abstract

Prostacyclin (PGI2) incubated in Human Platelet Rich Plasma (PRP); in Platelet Poor Plasma (PPP) or in Krebs-Ringer-Bicarbonate (KRB) during different periods of time on contractions of bovine coronary arteries and on the ADP platelet aggregative capacity of human PRP, were explored. It was documented that incubates in PRP or in PPP retain an antiaggregatory activity at higher levels and during a longer time than in KRB. On the other hand, PGI2 incubates in KRB exhibited only a relaxing activity on isolated bovine coronary arteries, whereas when incubated in PRP or in PPP presented a biphasic influence. The initial effects (evoked by incubates of 30 minutes) were distinctly relaxing but those obtained with later incubates (60--150 minutes) stimulated clearly the resting basal tone of the arteries. The possibility that the human plasma might have an enzyme(s) able to transform prostacyclin into a more stable material with human antiaggregatory platelet function and bovine coronary contracting capacity is discussed.

References

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Citations

Nov 1, 1980·Prostaglandins·M A Wynalda, F A Fitzpatrick
Feb 1, 1981·Prostaglandins·D D PiferC M Chesney
Nov 1, 1983·Prostaglandins·S J LyeJ R Challis
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Dec 1, 1985·Prostaglandins·A C PappK K Wu
Jan 1, 1981·Pharmacology & Therapeutics·J M Sullivan
Dec 1, 1984·Prostaglandins, Leukotrienes, and Medicine·R LewisG Beck
Sep 1, 1985·Prostaglandins, Leukotrienes, and Medicine·M A SchattnerM A Lazzari
May 1, 1986·Prostaglandins, Leukotrienes, and Medicine·M A ChaudA L Gimeno
Jan 1, 1983·General Pharmacology·E A Higgs, S Moncada
Feb 1, 1983·Prostaglandins, Leukotrienes, and Medicine·K E El TahirD J Betteridge
Jan 1, 1985·The Journal of Clinical Investigation·K K WuA C Papp
Apr 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M C AuclairP Lechat
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Jan 1, 1985·Annals of the New York Academy of Sciences·S Moncada, M W Radomski
Jan 1, 1985·Stroke; a Journal of Cerebral Circulation·R W SteinK K Wu
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Apr 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Y C ChenC H Wang

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